SCHEMBL1502695

SCHEMBL1502695

FC(F)(F)c1nc(Cl)c2c(-c3ccccc3)cccc2n1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNA5 P22460 2/20 0.53
KCNH2 Q12809 1/20 0.53
ENPP1 P22413 2/20 0.42
GAA P10253 2/20 0.41
MAPT P10636 2/20 0.41
ALDH1A1 P00352 1/20 0.41
RAB9A P51151 2/20 0.40
MEN1 O00255 2/20 0.40
POLB P06746 2/20 0.40
KMT2A Q03164 2/20 0.40
APAF1 O14727 1/20 0.40
USP2 O75604 1/20 0.40
BLM P54132 1/20 0.40
CCNE1 P24864 6/20 0.39
CDK2 P24941 6/20 0.39
CCNE2 O96020 5/20 0.39
CDK4 P11802 4/20 0.39
CCND1 P24385 4/20 0.39
JAK2 O60674 1/20 0.39
IGF1R P08069 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1502509 0.79 KCNA5 (0.52) KCNA5KCNH2GAAMAPTALDH1A1
SCHEMBL12169929 0.78 KCNH2 (0.51) KCNA5KCNH2GAAMAPTALDH1A1
SCHEMBL19619170 0.77 KCNA5 (0.42) KCNA5KCNH2MEN1POLBKMT2A
SCHEMBL8068675 0.76 ELANE (0.48) GAAMAPTALDH1A1RAB9AMEN1
SCHEMBL3119156 0.75 GAA (0.57) GAAMAPTALDH1A1RAB9ACCNE1
SCHEMBL29416441 0.75 GAA (0.57) GAAMAPTALDH1A1RAB9ACCNE1
SCHEMBL2369443 0.74 ALDH1A1 (0.55) GAAMAPTALDH1A1RAB9AKMT2A
SCHEMBL8073672 0.73 ELANE (0.51) KCNA5KCNH2GAAALDH1A1RAB9A
SCHEMBL25382124 0.72 DCPS (0.52) KCNA5KCNH2MAPTRAB9AMEN1
SCHEMBL31243210 0.72 DCPS (0.52) KCNA5KCNH2MAPTRAB9AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250230144-A1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2025-07-17 US disclosed
US-20230322726-A1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2023-10-12 US disclosed
US-20230322726-A1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2023-10-12 US disclosed
US-20220324836-A1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2022-10-13 US disclosed
EP-3575288-B1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2021-10-27 EP disclosed
EP-3575288-B1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2021-10-27 EP disclosed
US-11008306-B2 Quinazolines as potassium ion channel inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2021-05-18 US disclosed
US-11008306-B2 Quinazolines as potassium ion channel inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2021-05-18 US disclosed
US-20200255407-A1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2020-08-13 US disclosed
US-20200255407-A1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2020-08-13 US disclosed
US-20140031345-A1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2014-01-30 US disclosed
US-20140031345-A1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2014-01-30 US disclosed
US-8575184-B2 Quinazolines as potassium ion channel inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2013-11-05 US disclosed
US-8575184-B2 Quinazolines as potassium ion channel inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2013-11-05 US disclosed
CN-102753535-A Quinazolines as Potassium Channel Inhibitors BRISTOL MYERS SQUIBB CO 2012-10-24 CN disclosed
US-20120232068-A1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS BRISTON-MYERS SQUIBB COMPANY (US) 2012-09-13 US disclosed
US-20120232068-A1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS BRISTON-MYERS SQUIBB COMPANY (US) 2012-09-13 US disclosed
EP-2473487-A1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS Bristol-Myers Squibb Company (US) 2012-07-11 EP disclosed
WO-2011028741-A1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2011-03-10 WO disclosed
WO-2011028741-A1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2011-03-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220324836-A1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS KCNJ4, KCNK4, KCNQ4 KCNA5 48/4885KCNH2 9/4885ENPP1 4035/4885
US-20250230144-A1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS KCNJ4, KCNK4, KCNQ4 KCNA5 48/4885KCNH2 9/4885ENPP1 4035/4885
US-20200255407-A1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS KCNJ4, KCNK4, KCNQ4 KCNA5 48/4885KCNH2 9/4885ENPP1 4035/4885
US-20120232068-A1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS KCNJ4, KCNH3, KCNQ4 KCNA5 46/4885KCNH2 7/4885ENPP1 4171/4885
US-11008306-B2 Quinazolines as potassium ion channel inhibitors KCNJ4, KCNK4, KCNQ4 KCNA5 48/4885KCNH2 9/4885ENPP1 4035/4885
US-20140031345-A1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS KCNJ4, KCNK4, KCNQ4 KCNA5 48/4885KCNH2 9/4885ENPP1 4035/4885
US-20230322726-A1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS KCNJ4, KCNK4, KCNQ4 KCNA5 48/4885KCNH2 9/4885ENPP1 4035/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.