SCHEMBL15027031

SCHEMBL15027031

CCCCCC/C=C\COC(=O)CCCCCCCC

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.64
DGKA P23743 1/20 0.63
PRKCE Q02156 1/20 0.60
PRKCQ Q04759 1/20 0.60
PRKCD Q05655 1/20 0.60
PRKCA P17252 1/20 0.60
TERT O14746 3/20 0.59
PTPN1 P18031 3/20 0.59
PPARG P37231 3/20 0.59
PPARD Q03181 3/20 0.59
PPARA Q07869 3/20 0.59
FAAH O00519 3/20 0.59
CYP1A2 P05177 2/20 0.59
MAPT P10636 2/20 0.59
CYP2C19 P33261 2/20 0.59
BLM P54132 2/20 0.59
HSD17B10 Q99714 2/20 0.59
FABP4 P15090 2/20 0.59
KMT2A Q03164 2/20 0.59
GMNN O75496 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29119147 1.00 TSHR (0.64) TSHRDGKAPRKCEPRKCQPRKCD
SCHEMBL28936532 1.00 TSHR (0.64) TSHRDGKAPRKCEPRKCQPRKCD
SCHEMBL30592524 1.00 TSHR (0.64) TSHRDGKAPRKCEPRKCQPRKCD
SCHEMBL9348758 1.00 TSHR (0.64) TSHRDGKAPRKCEPRKCQPRKCD
SCHEMBL10084760 1.00 TSHR (0.64) TSHRDGKAPRKCEPRKCQPRKCD
SCHEMBL15027037 1.00 TSHR (0.64) TSHRDGKAPRKCEPRKCQPRKCD
SCHEMBL31203100 1.00 TSHR (0.64) TSHRDGKAPRKCEPRKCQPRKCD
SCHEMBL29119174 1.00 TSHR (0.64) TSHRDGKAPRKCEPRKCQPRKCD
SCHEMBL9348765 1.00 TSHR (0.64) TSHRDGKAPRKCEPRKCQPRKCD
SCHEMBL29269579 1.00 TSHR (0.64) TSHRDGKAPRKCEPRKCQPRKCD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3860561-B1 BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS ALNYLAM PHARMACEUTICALS INC (US) 2023-06-21 EP disclosed
WO-2021237055-A1 FUNCTIONAL LIPID DERIVATIVES AND USES THEREOF OHIO STATE INNOVATION FOUNDATION (US) 2021-11-25 WO disclosed
WO-2019051289-A1 LIPID NANOPARTICLE FORMULATIONS OF NON-VIRAL, CAPSID-FREE DNA VECTORS GENERATION BIO CO. (US) 2019-03-14 WO disclosed
US-20170267631-A1 IONIZABLE CATIONIC LIPID FOR RNA DELIVERY ARCTURUS THERAPEUTICS INC (US) 2017-09-21 US disclosed
US-20170233734-A1 NUCLEIC ACID LIPID PARTICLE FORMULATIONS ALNYLAM PHARMACEUTICALS INC (US) 2017-08-17 US disclosed
US-9687448-B2 Nucleic acid lipid particle formulations ALNYLAM PHARMACEUTICALS, INC. (US) 2017-06-27 US disclosed
US-9682922-B2 Biodegradable lipids for the delivery of active agents ALNYLAM PHARMACEUTICALS, INC. (US) 2017-06-20 US disclosed
EP-2575764-B1 BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS ALNYLAM PHARMACEUTICALS INC (US) 2017-04-19 EP disclosed
US-20170101370-A1 IONIZABLE CATIONIC LIPID FOR RNA DELIVERY ARCTURUS THERAPEUTICS INC (US) 2017-04-13 US disclosed
US-9593077-B2 Ionizable cationic lipid for RNA delivery ARCTURUS THERAPEUTICS, INC. (US) 2017-03-14 US disclosed
US-9567296-B2 Ionizable cationic lipid for RNA delivery ARCTURUS THERAPEUTICS, INC. (US) 2017-02-14 US disclosed
US-20160009637-A1 BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS BANK OF AMERICA, N.A. 2016-01-14 US disclosed
US-20150306039-A1 IMPROVED NUCLEIC ACID LIPID PARTICLE FORMULATIONS BANK OF AMERICA, N.A. 2015-10-29 US disclosed
US-9012498-B2 Biodegradable lipids for the delivery of active agents ALNYLAM PHARMACEUTICALS, INC. (US) 2015-04-21 US disclosed
US-20140308304-A1 LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS ALNYLAM PHARMACEUTICALS, INC. 2014-10-16 US disclosed
WO-2014089239-A1 IMPROVED NUCLEIC ACID LIPID PARTICLE FORMULATIONS ALNYLAM PHARMACEUTICALS, INC. (US) 2014-06-12 WO disclosed
WO-2013086354-A1 BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS ALNYLAM PHARMACEUTICALS, INC. (US) 2013-06-13 WO disclosed
WO-2013086373-A1 LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS ALNYLAM PHARMACEUTICALS, INC. (US) 2013-06-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160009637-A1 BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS LIPA, CETP, APOB TSHR 2854/4885DGKA 336/4885PRKCE 3874/4885
US-20170101370-A1 IONIZABLE CATIONIC LIPID FOR RNA DELIVERY NSUN3, METTL16, SOAT1 TSHR 948/4885DGKA 3053/4885PRKCE 4310/4885
US-20140308304-A1 LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS NPC1L1, NPC1, CETP TSHR 2889/4885DGKA 394/4885PRKCE 3720/4885
US-20170267631-A1 IONIZABLE CATIONIC LIPID FOR RNA DELIVERY RNASEH1, L3MBTL1, NPC1L1 TSHR 958/4885DGKA 2768/4885PRKCE 4549/4885
US-20170233734-A1 NUCLEIC ACID LIPID PARTICLE FORMULATIONS LIPA, ABHD16A, CETP TSHR 3260/4885DGKA 373/4885PRKCE 3513/4885
US-20150306039-A1 IMPROVED NUCLEIC ACID LIPID PARTICLE FORMULATIONS LIPA, NPC1L1, CETP TSHR 3683/4885DGKA 423/4885PRKCE 3809/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.