Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | BCHE | P06276 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPY1R | P25929 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPY2R | P49146 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.33 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.32 |
| ▸ | MPO | P05164 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1503319 | 0.84 | KMT2A (0.38) | KMT2ABCHELMNAMEN1KDM4E | |
| SCHEMBL1503138 | 0.78 | KMT2A (0.48) | KMT2AMEN1KDM4EMAPTTRPV6 | |
| SCHEMBL1503322 | 0.70 | MAPT (0.34) | KMT2ALMNAMAPT | |
| SCHEMBL2221780 | 0.70 | KDM4E (0.47) | KMT2AMEN1KDM4ETRPV6MPO | |
| SCHEMBL12444364 | 0.69 | ALOX5 (0.40) | KMT2ALMNAMEN1KDM4EHTT | |
| SCHEMBL1503131 | 0.68 | BCHE (0.39) | KMT2ABCHEMEN1 | |
| SCHEMBL1503187 | 0.68 | ALDH1A1 (0.41) | KMT2ALMNAMEN1KDM4EMAPT | |
| SCHEMBL1503238 | 0.66 | HDAC1 (0.49) | KMT2AKDM4ETRPV6MPO | |
| SCHEMBL1503229 | 0.64 | MAPT (0.46) | KMT2ALMNAKDM4EMAPT | |
| SCHEMBL27833103 | 0.63 | KDM4E (0.46) | KMT2AMEN1KDM4ETRPV6MPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300433-A1 | HIV INTEGRASE INHIBITORS FROM PYRIDOXINE | Ambrilia Biopharma Inc. (CA) | 2011-03-30 | — | — | EP | disclosed |
| WO-2009146555-A1 | HIV INTEGRASE INHIBITORS FROM PYRIDOXINE | AMBRILIA BIOPHARMA INC. (CA) | 2009-12-10 | — | — | WO | disclosed |