Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | BCHE | P06276 | 7/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NPY1R | P25929 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPY2R | P49146 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1503317 | 0.84 | KMT2A (0.35) | KMT2ABCHEKDM4ELMNANPY1R | |
| SCHEMBL1503138 | 0.80 | KMT2A (0.48) | KMT2AKDM4EMAPTALDH1A1L3MBTL1 | |
| SCHEMBL1503322 | 0.76 | MAPT (0.34) | KMT2ALMNAMAPTALDH1A1L3MBTL1 | |
| SCHEMBL1503131 | 0.75 | BCHE (0.39) | KMT2ABCHEMEN1 | |
| SCHEMBL2221780 | 0.71 | KDM4E (0.47) | KMT2AKDM4EALDH1A1L3MBTL1MEN1 | |
| SCHEMBL12444364 | 0.70 | ALOX5 (0.40) | KMT2AKDM4ELMNAHTTMAPT | |
| SCHEMBL1503187 | 0.69 | ALDH1A1 (0.41) | KMT2AKDM4ELMNAMAPTALDH1A1 | |
| SCHEMBL1503238 | 0.67 | HDAC1 (0.49) | KMT2AKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL4306646 | 0.67 | HCAR2 (0.35) | KMT2A | |
| SCHEMBL15746784 | 0.66 | BCHE (0.37) | KMT2ABCHEMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300433-A1 | HIV INTEGRASE INHIBITORS FROM PYRIDOXINE | Ambrilia Biopharma Inc. (CA) | 2011-03-30 | — | — | EP | disclosed |
| WO-2009146555-A1 | HIV INTEGRASE INHIBITORS FROM PYRIDOXINE | AMBRILIA BIOPHARMA INC. (CA) | 2009-12-10 | — | — | WO | disclosed |