Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTR4 | Q13639 | 7/20 | 0.33 |
| ▸ | PLAT | P00750 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13453100 | 0.81 | PKM (0.34) | PKML3MBTL1POLBKMT2AMAPT | |
| SCHEMBL21733293 | 0.81 | PKM (0.46) | PKML3MBTL1POLBKMT2AMAPT | |
| SCHEMBL8250610 | 0.75 | SMN1; SMN2 (0.56) | PKMKMT2AMAPT | |
| SCHEMBL437505 | 0.74 | PKM (0.39) | PKML3MBTL1POLBKMT2AMAPT | |
| SCHEMBL408238 | 0.74 | PKM (0.39) | PKML3MBTL1POLBKMT2AMAPT | |
| SCHEMBL15025446 | 0.72 | HTR4 (0.33) | HTR4LRRK2 | |
| SCHEMBL13452967 | 0.71 | GAA (0.30) | MAPT | |
| SCHEMBL12049735 | 0.69 | L3MBTL1 (0.41) | PKML3MBTL1POLBKMT2AMAPT | |
| SCHEMBL3052184 | 0.69 | PDE10A (0.44) | L3MBTL1KMT2AMAPT | |
| SCHEMBL314745 | 0.67 | L3MBTL1 (0.41) | PKML3MBTL1POLBKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788086-B1 | SUBSTITUTED PYRAZOLES AS MGLU5 RECEPTOR MODULATORS | BOEHRINGER INGELHEIM INT (DE) | 2016-10-12 | — | — | EP | disclosed |
| WO-2013083591-A1 | SUBSTITUTED PYRAZOLES AS MGLU5 RECEPTOR MODULATORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-06-13 | — | — | WO | disclosed |