Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | ALOX15B | O15296 | 1/20 | 0.40 |
| ▸ | ADCY1 | Q08828 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25375224 | 0.83 | PKM (0.34) | PKML3MBTL1KMT2APOLBMAPT | |
| SCHEMBL13453100 | 0.83 | PKM (0.34) | PKML3MBTL1KMT2APOLBMAPT | |
| SCHEMBL15033291 | 0.81 | PKM (0.38) | PKML3MBTL1KMT2APOLBMAPT | |
| SCHEMBL13179147 | 0.80 | L3MBTL1 (0.49) | PKML3MBTL1KMT2APOLBMAPT | |
| SCHEMBL18800277 | 0.80 | L3MBTL1 (0.49) | PKML3MBTL1KMT2APOLBMAPT | |
| SCHEMBL437505 | 0.79 | PKM (0.39) | PKML3MBTL1KMT2APOLBMAPT | |
| SCHEMBL408238 | 0.79 | PKM (0.39) | PKML3MBTL1KMT2APOLBMAPT | |
| SCHEMBL13193927 | 0.78 | L3MBTL1 (0.47) | PKML3MBTL1KMT2APOLBMAPT | |
| SCHEMBL11336747 | 0.77 | ALDH1A1 (0.46) | PKML3MBTL1KMT2APOLBMAPT | |
| SCHEMBL14305100 | 0.76 | L3MBTL1 (0.43) | PKML3MBTL1KMT2APOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020036979-A1 | PYRROLO[1,2-B]PYRIDAZINE DERIVATIVES AS IRAK4 INHIBITORS | GILEAD SCIENCES, INC. (US) | 2020-02-20 | — | — | WO | disclosed |