Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 2/20 | 0.46 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 6/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 6/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA5A | P35218 | 1/20 | 0.42 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SNCA | P37840 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | TERT | O14746 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16419751 | 0.94 | KEAP1 (0.44) | HSD17B1HSD17B2HDAC3HDAC1HDAC6 | |
| SCHEMBL15036880 | 0.88 | MAPT (0.43) | HSD17B1HSD17B2CA1CA2CA5A | |
| SCHEMBL15244877 | 0.85 | KEAP1 (0.55) | HSD17B1HSD17B2KEAP1NFE2L2 | |
| SCHEMBL16419741 | 0.83 | OGT (0.40) | CA1CA2CA5ACA5BMAPT | |
| SCHEMBL16603465 | 0.80 | KEAP1 (0.55) | HSD17B1HSD17B2KEAP1NFE2L2 | |
| SCHEMBL15036886 | 0.79 | KEAP1 (0.48) | HSD17B1HSD17B2HDAC3KEAP1NFE2L2 | |
| SCHEMBL15036900 | 0.76 | KEAP1 (0.48) | HSD17B1HSD17B2KEAP1NFE2L2MAPT | |
| SCHEMBL15036894 | 0.76 | CYP1B1 (0.58) | KEAP1NFE2L2CA1CA2CA5A | |
| SCHEMBL15036885 | 0.74 | KEAP1 (0.44) | HSD17B1HSD17B2HDAC3HDAC1HDAC6 | |
| SCHEMBL15036891 | 0.73 | CYP1B1 (0.41) | HSD17B1HSD17B2HDAC3HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9469616-B2 | Cyclic compounds and methods of making and using the same | CELLCEUTIX CORPORATION (US) | 2016-10-18 | — | — | US | disclosed |
| US-9469616-B2 | Cyclic compounds and methods of making and using the same | CELLCEUTIX CORPORATION (US) | 2016-10-18 | — | — | US | disclosed |
| US-20150031738-A1 | CYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | UNIVERSITY OF MASSACHUSETTS (US) | 2015-01-29 | — | — | US | disclosed |
| US-20150031738-A1 | CYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | UNIVERSITY OF MASSACHUSETTS (US) | 2015-01-29 | — | — | US | disclosed |
| WO-2013090185-A1 | CYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | POLYMEDIX, INC. (US) | 2013-06-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150031738-A1 | CYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | MUC1, TLR3, ALG1 | HSD17B1 2120/4885HSD17B2 2452/4885HDAC3 76/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.