Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT2 | P34897 | 1/20 | 0.53 |
| ▸ | ALK | Q9UM73 | 9/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | IGF1R | P08069 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | S100A4 | P26447 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1089733 | 0.89 | CXCR4 (0.56) | SHMT2ALKALDH1A1IGF1RSMN1; SMN2 | |
| SCHEMBL29438256 | 0.86 | SHMT2 (0.49) | SHMT2ALKALDH1A1IGF1RSMN1; SMN2 | |
| SCHEMBL23582477 | 0.86 | SHMT2 (0.58) | SHMT2ALDH1A1SMN1; SMN2USP2MAPT | |
| SCHEMBL29913989 | 0.86 | SHMT2 (0.58) | SHMT2ALDH1A1SMN1; SMN2USP2MAPT | |
| SCHEMBL23582563 | 0.86 | SHMT2 (0.58) | SHMT2ALDH1A1SMN1; SMN2USP2MAPT | |
| SCHEMBL2635948 | 0.84 | ALDH1A1 (0.54) | SHMT2ALDH1A1SMN1; SMN2POLBHTT | |
| SCHEMBL29438234 | 0.84 | ALDH1A1 (0.54) | SHMT2ALDH1A1SMN1; SMN2POLBHTT | |
| SCHEMBL12185358 | 0.84 | ALDH1A1 (0.54) | SHMT2ALDH1A1SMN1; SMN2POLBHTT | |
| SCHEMBL12184979 | 0.83 | ALK (0.51) | ALKALDH1A1IGF1RMEN1KMT2A | |
| SCHEMBL12185364 | 0.81 | ALK (0.56) | ALKIGF1RSMN1; SMN2JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8716281-B2 | Pyrimidine compounds that inhibit anaplastic lymphoma kinase | AMGEN INC. (US) | 2014-05-06 | — | — | US | disclosed |
| US-20130158019-A1 | PYRIMIDINE COMPOUNDS THAT INHIBIT ANAPLASTIC LYMPHOMA KINASE | AMGEN INC. (US) | 2013-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130158019-A1 | PYRIMIDINE COMPOUNDS THAT INHIBIT ANAPLASTIC LYMPHOMA KINASE | DCK, DTYMK, TYMS | SHMT2 1136/4885ALK 53/4885ALDH1A1 725/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.