Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT2 | P34897 | 1/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 9/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | IGF1R | P08069 | 3/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23582215 | 0.89 | ALDH1A1 (0.48) | SHMT2ALDH1A1 | |
| SCHEMBL25299698 | 0.88 | ALK (0.50) | ALKALDH1A1IGF1RMAP4K4 | |
| SCHEMBL25262307 | 0.88 | ALK (0.50) | ALKALDH1A1IGF1RMAP4K4 | |
| SCHEMBL15037240 | 0.86 | SHMT2 (0.53) | SHMT2ALKALDH1A1IGF1RJAK2 | |
| SCHEMBL1089733 | 0.84 | CXCR4 (0.56) | SHMT2ALKALDH1A1IGF1RJAK2 | |
| SCHEMBL23582563 | 0.81 | SHMT2 (0.58) | SHMT2ALDH1A1JAK2JAK3SMN1; SMN2 | |
| SCHEMBL29913989 | 0.81 | SHMT2 (0.58) | SHMT2ALDH1A1JAK2JAK3SMN1; SMN2 | |
| SCHEMBL23582477 | 0.81 | SHMT2 (0.58) | SHMT2ALDH1A1JAK2JAK3SMN1; SMN2 | |
| SCHEMBL2635948 | 0.79 | ALDH1A1 (0.54) | SHMT2ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29438234 | 0.79 | ALDH1A1 (0.54) | SHMT2ALDH1A1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12459915-B2 | Biaryl derivative useful as diacylglycerol acyltransferase 2 inhibitor, and use thereof | LG CHEM, LTD. (KR) | 2025-11-04 | — | — | US | disclosed |
| US-20230322706-A1 | NOVEL BIARYL DERIVATIVE USEFUL AS DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITOR, AND USE THEREOF | LG CHEM, LTD. (KR) | 2023-10-12 | — | — | US | disclosed |
| WO-2022050749-A1 | NOVEL BIARYL DERIVATIVE USEFUL AS DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITOR, AND USE THEREOF | 주식회사 엘지화학 | 2022-03-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230322706-A1 | NOVEL BIARYL DERIVATIVE USEFUL AS DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITOR, AND USE THEREOF | DGAT2, DGAT1, MOGAT2 | SHMT2 788/4885ALK 2517/4885ALDH1A1 600/4885 |
| US-12459915-B2 | Biaryl derivative useful as diacylglycerol acyltransferase 2 inhibitor, and use thereof | DGAT2, DGAT1, LCAT | SHMT2 1053/4885ALK 2359/4885ALDH1A1 656/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.