Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.61 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.53 |
| ▸ | CCR1 | P32246 | 11/20 | 0.52 |
| ▸ | NAMPT | P43490 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.50 |
| ▸ | LIPE | Q05469 | 1/20 | 0.50 |
| ▸ | PRCP | P42785 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13588778 | 0.87 | KCNH2 (0.64) | KCNH2HRH3ADAMTS5CCR1NAMPT | |
| SCHEMBL15045209 | 0.84 | ALDH1A1 (0.54) | KCNH2HRH3 | |
| SCHEMBL19954317 | 0.83 | KCNH2 (0.52) | KCNH2HRH3ADAMTS5CCR1CA12 | |
| SCHEMBL19954277 | 0.83 | KCNH2 (0.52) | KCNH2HRH3ADAMTS5CCR1CA12 | |
| SCHEMBL24340329 | 0.82 | ADAMTS5 (0.61) | KCNH2HRH3ADAMTS5CCR1 | |
| SCHEMBL23138269 | 0.82 | KCNH2 (0.58) | KCNH2HRH3ADAMTS5CCR1NAMPT | |
| SCHEMBL2376087 | 0.80 | HDAC8 (0.59) | — | |
| SCHEMBL2376093 | 0.80 | HDAC8 (0.59) | — | |
| SCHEMBL1473424 | 0.78 | QDPR (0.61) | KCNH2HRH3CA12CA1CA2 | |
| SCHEMBL5490962 | 0.78 | KCNH2 (0.56) | KCNH2HRH3CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2604601-A1 | HETERO RING COMPOUND | Astellas Pharma Inc. (JP) | 2013-06-19 | — | — | EP | disclosed |