Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB8 | P28062 | 9/20 | 0.61 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.61 |
| ▸ | PSMD11 | O00231 | 1/20 | 0.61 |
| ▸ | PSMD12 | O00232 | 1/20 | 0.61 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.61 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.61 |
| ▸ | PSMD3 | O43242 | 1/20 | 0.61 |
| ▸ | PSMC3 | P17980 | 1/20 | 0.61 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.61 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.61 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.61 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.61 |
| ▸ | PSMA4 | P25789 | 1/20 | 0.61 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.61 |
| ▸ | PSMA5 | P28066 | 1/20 | 0.61 |
| ▸ | PSMB4 | P28070 | 1/20 | 0.61 |
| ▸ | PSMB6 | P28072 | 1/20 | 0.61 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.61 |
| ▸ | PSMC2 | P35998 | 1/20 | 0.61 |
| ▸ | PSMB10 | P40306 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL67941 | 0.75 | CA12 (0.68) | RAB9AGABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL26665257 | 0.74 | KDM4E (0.59) | NPC1RAB9AGABRG2GABRB3GABRA5 | |
| SCHEMBL27715902 | 0.74 | CA12 (0.71) | GABRG2GABRB3GABRA5GABRA3CA12 | |
| SCHEMBL31420315 | 0.73 | CDK8 (0.47) | GABRG2GABRB3GABRA5GABRA3CA12 | |
| SCHEMBL12754449 | 0.73 | GPR119 (0.53) | NPC1RAB9AGPR119GABRG2GABRB3 | |
| SCHEMBL6434655 | 0.72 | GLRA3 (0.62) | NPC1RAB9AGABRG2GABRB3GABRA5 | |
| SCHEMBL28605620 | 0.72 | KDM4E (0.74) | NPC1RAB9AGPR119 | |
| SCHEMBL31247990 | 0.72 | KDM4E (0.74) | NPC1RAB9AGPR119 | |
| SCHEMBL1429971 | 0.72 | NPC1 (0.60) | NPC1RAB9AVDR | |
| SCHEMBL6165586 | 0.72 | NOTUM (0.54) | NPC1RAB9AGABRG2GABRB3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9758485-B2 | Compounds for controlling arthropods | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2017-09-12 | — | — | US | disclosed |
| US-20170204073-A1 | COMPOUNDS FOR NONSENSE SUPPRESSION, AND METHODS FOR THEIR USE | PTC THERAPEUTICS, INC. (US) | 2017-07-20 | — | — | US | disclosed |
| US-9611230-B2 | 1,3,4-oxadiazole benzoic acid compounds and their use for nonsense suppression and the treatment of disease | PTC THERAPEUTICS, INC. (US) | 2017-04-04 | — | — | US | disclosed |
| US-20160297765-A1 | NOVEL COMPOUNDS FOR CONTROLLING ARTHROPODS | ELANCO ANIMAL HEALTH GMBH (DE) | 2016-10-13 | — | — | US | disclosed |
| US-20160278379-A1 | NOVEL COMPOUNDS FOR CONTROLLING ARTHROPODS | ELANCO ANIMAL HEALTH GMBH (DE) | 2016-09-29 | — | — | US | disclosed |
| EP-3067053-A1 | COMPOUNDS FOR NONSENSE SUPPRESSION, AND METHODS FOR THEIR USE | PTC Therapeutics, Inc. (US) | 2016-09-14 | — | — | EP | disclosed |
| EP-1815206-B1 | COMPOUNDS FOR NONSENSE SUPPRESSION, AND METHODS FOR THEIR USE | PTC THERAPEUTICS INC (US) | 2016-04-06 | — | — | EP | disclosed |
| EP-2939674-A1 | COMPOUNDS FOR NONSENSE SUPPRESSION, AND METHODS FOR THEIR USE | PTC Therapeutics, Inc. (US) | 2015-11-04 | — | — | EP | disclosed |
| EP-2311455-A1 | Compounds for nonsense suppression, and methods for their use | PTC Therapeutics, Inc. (US) | 2011-04-20 | — | — | EP | disclosed |
| EP-2301536-A1 | Pyrazole or triazole compounds and their use for the manufacture of a medicament for treating somatic mutation-related diseases | PTC Therapeutics, Inc. (US) | 2011-03-30 | — | — | EP | disclosed |
| EP-2301538-A1 | Compounds for nonsense suppression, and methods for their use | PTC Therapeutics, Inc. (US) | 2011-03-30 | — | — | EP | disclosed |
| US-20090253699-A1 | Compounds for Nonsense Suppression, and Methods for Their Use | PCT THERAPEUTICS, INC. (US) | 2009-10-08 | — | — | US | disclosed |
| EP-1815206-A1 | COMPOUNDS FOR NONSENSE SUPPRESSION, AND METHODS FOR THEIR USE | PTC Therapeutics, Inc. (US) | 2007-08-08 | — | — | EP | disclosed |
| WO-2006044456-A1 | COMPOUNDS FOR NONSENSE SUPPRESSION, AND METHODS FOR THEIR USE | PTC THERAPEUTICS, INC. (US) | 2006-04-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253699-A1 | Compounds for Nonsense Suppression, and Methods for Their Use | NSUN2, UPF1, NSUN3 | PSMB8 1127/4885PSMB11 550/4885PSMD11 645/4885 |
| US-20170204073-A1 | COMPOUNDS FOR NONSENSE SUPPRESSION, AND METHODS FOR THEIR USE | NSUN2, UPF1, NSUN3 | PSMB8 1127/4885PSMB11 550/4885PSMD11 645/4885 |
| US-20160278379-A1 | NOVEL COMPOUNDS FOR CONTROLLING ARTHROPODS | CYP4X1, CYP4B1, SERPINB6 | PSMB8 2144/4885PSMB11 620/4885PSMD11 1537/4885 |
| US-20160297765-A1 | NOVEL COMPOUNDS FOR CONTROLLING ARTHROPODS | CYP4X1, CYP4B1, SERPINB6 | PSMB8 2144/4885PSMB11 620/4885PSMD11 1537/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.