Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | AGER | Q15109 | 2/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15043866 | 0.92 | GABRB2 (0.45) | MAPTSMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL15033980 | 0.91 | MAPT (0.52) | MAPTSMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL15046452 | 0.90 | MAPT (0.52) | MAPTSMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL15046475 | 0.88 | RAB9A (0.51) | MAPTSMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL15046472 | 0.87 | ABCB1 (0.49) | MAPTSMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL15033992 | 0.87 | MAPT (0.52) | MAPTSMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL15046477 | 0.81 | GRM5 (0.43) | MAPTGABRA2GABRB2ALDH1A1 | |
| SCHEMBL15033978 | 0.80 | GABRA2 (0.43) | MAPTSMN1; SMN2LMNAGABRA2GABRB2 | |
| SCHEMBL15033985 | 0.80 | SMN1; SMN2 (0.52) | MAPTSMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL15046461 | 0.79 | GABRA2 (0.42) | MAPTSMN1; SMN2RAB9ALMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013087806-A1 | PIPERAZINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLU5 RECEPTORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-06-20 | — | — | WO | disclosed |