Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1504502 | 0.86 | LMNA (0.50) | ALDH1A1L3MBTL1LMNAHSD17B10TDP1 | |
| SCHEMBL2022640 | 0.84 | GAA (0.45) | ALDH1A1L3MBTL1LMNAHSD17B10TDP1 | |
| SCHEMBL1504529 | 0.80 | ALDH1A1 (0.46) | ALDH1A1L3MBTL1LMNAHSD17B10TDP1 | |
| SCHEMBL2459873 | 0.78 | KMT2A (0.52) | ALDH1A1L3MBTL1LMNAHSD17B10KDM4E | |
| SCHEMBL4876099 | 0.76 | MAPK14 (0.46) | ALDH1A1LMNAMEN1KMT2AMAPT | |
| SCHEMBL25077892 | 0.76 | ALDH1A1 (0.43) | ALDH1A1L3MBTL1LMNAHSD17B10TDP1 | |
| SCHEMBL30159532 | 0.75 | ALDH1A1 (0.47) | ALDH1A1L3MBTL1LMNAHSD17B10KDM4E | |
| SCHEMBL24849951 | 0.75 | ALDH1A1 (0.47) | ALDH1A1L3MBTL1LMNAHSD17B10KDM4E | |
| SCHEMBL27795659 | 0.75 | ACHE (0.42) | ALDH1A1LMNATDP1KDM4EGAA | |
| SCHEMBL1504800 | 0.75 | MAPK14 (0.47) | ALDH1A1L3MBTL1LMNAKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8173684-B2 | Pyridone derivatives as p38α MAPK inhibitors | ASTELLAS PHARMA INC. (JP) | 2012-05-08 | — | — | US | disclosed |
| EP-2155683-B1 | PYRIDONE DERIVATIVES AS P38A MAPK INHIBITORS | ASTELLAS PHARMA INC (JP) | 2011-03-16 | — | — | EP | disclosed |
| CN-101675034-A | Pyridone derivatives as p38a mapk inhibitors | ASTELLAS PHARMA INC | 2010-03-17 | — | — | CN | disclosed |
| US-20100063098-A1 | PYRIDONE DERIVATIVES AS P38A MAPK INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2010-03-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100063098-A1 | PYRIDONE DERIVATIVES AS P38A MAPK INHIBITORS | MAPK1, MAPK6, MAPK3 | ALDH1A1 671/4885L3MBTL1 2628/4885LMNA 2734/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.