Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 10/20 | 0.61 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.47 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | DPP4 | P27487 | 1/20 | 0.45 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1504939 | 0.93 | ADAM17 (0.60) | ADAM17MEN1KMT2A | |
| SCHEMBL1504974 | 0.93 | ADAM17 (0.60) | ADAM17ADAM10MMP1MMP3MEN1 | |
| SCHEMBL1504840 | 0.92 | ADAM17 (0.61) | ADAM17CHRM4HDAC1HDAC2MEN1 | |
| SCHEMBL1504934 | 0.91 | ADAM17 (0.63) | ADAM17 | |
| SCHEMBL1504967 | 0.85 | ADAM17 (0.65) | ADAM17ADAM10MMP1MMP3 | |
| SCHEMBL1504684 | 0.85 | ALDH1A1 (0.42) | ADAM17MEN1MAPK1KMT2A | |
| SCHEMBL1504704 | 0.84 | ADAM17 (0.66) | ADAM17ADAM10MMP1MMP3 | |
| SCHEMBL1504530 | 0.84 | ADAM17 (0.60) | ADAM17ADAM10MMP1MMP3 | |
| SCHEMBL1504784 | 0.84 | ADAM17 (0.43) | ADAM17ADAM10MMP3 | |
| SCHEMBL1504797 | 0.84 | ADAM17 (0.60) | ADAM17ADAM10MMP1MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011033009-A1 | N- [2-HYDROXYCARBAMOYL-2- (PIPERAZINYL) ETHYL] BENZAMIDE COMPOUNDS, THEIR PREPARATION AND THEIR USE AS TACE INHIBITORS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2011-03-24 | — | — | WO | disclosed |