Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 7/20 | 0.61 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1504934 | 0.92 | ADAM17 (0.63) | ADAM17MAOBSLC6A5ALDH1A1 | |
| SCHEMBL1504974 | 0.92 | ADAM17 (0.60) | ADAM17MAOBKMT2AMEN1LMNA | |
| SCHEMBL1504939 | 0.92 | ADAM17 (0.60) | ADAM17POLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL1504779 | 0.92 | ADAM17 (0.61) | ADAM17CHRM4KMT2AMEN1HDAC1 | |
| SCHEMBL10276029 | 0.85 | ADAM17 (0.61) | ADAM17CHRM4NR4A2POLBMAOB | |
| SCHEMBL1504684 | 0.82 | ALDH1A1 (0.42) | ADAM17POLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL1504784 | 0.81 | ADAM17 (0.43) | ADAM17POLBALDH1A1 | |
| SCHEMBL1504797 | 0.81 | ADAM17 (0.60) | ADAM17ALDH1A1 | |
| SCHEMBL1504530 | 0.81 | ADAM17 (0.60) | ADAM17ALDH1A1 | |
| SCHEMBL1504967 | 0.79 | ADAM17 (0.65) | ADAM17ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011033009-A1 | N- [2-HYDROXYCARBAMOYL-2- (PIPERAZINYL) ETHYL] BENZAMIDE COMPOUNDS, THEIR PREPARATION AND THEIR USE AS TACE INHIBITORS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2011-03-24 | — | — | WO | disclosed |