Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 3/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.47 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1504652 | 0.86 | HDAC4 (0.54) | HDAC4HDAC1KCNH2TSHRCHRM4 | |
| SCHEMBL10476107 | 0.78 | CHRM4 (0.53) | HDAC4HDAC1KCNH2CHRM4CA12 | |
| SCHEMBL10276683 | 0.76 | CHRM4 (0.54) | HDAC4HDAC1KCNH2CHRM4CA12 | |
| SCHEMBL10276681 | 0.76 | CHRM4 (0.54) | HDAC4HDAC1KCNH2CHRM4CA12 | |
| SCHEMBL1221259 | 0.70 | ALDH1A1 (0.56) | HDAC4HDAC1KCNH2RECQLMCHR1 | |
| SCHEMBL24673250 | 0.70 | SIGMAR1 (0.56) | APOBEC3ARECQLAPOBEC3GALDH1A1POLB | |
| SCHEMBL3312142 | 0.70 | KMT2A (0.69) | TSHRAPOBEC3ARECQLAPOBEC3GALDH1A1 | |
| SCHEMBL24673260 | 0.69 | APOBEC3A (0.51) | TSHRAPOBEC3ARECQLAPOBEC3GALDH1A1 | |
| SCHEMBL4486386 | 0.69 | KDM4E (0.78) | TSHRCA12CA2CA9ALDH1A1 | |
| SCHEMBL9720752 | 0.69 | DRD4 (0.77) | CA12CA2CA9POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011033009-A1 | N- [2-HYDROXYCARBAMOYL-2- (PIPERAZINYL) ETHYL] BENZAMIDE COMPOUNDS, THEIR PREPARATION AND THEIR USE AS TACE INHIBITORS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2011-03-24 | — | — | WO | disclosed |