Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 6/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.40 |
| ▸ | TOP2A | P11388 | 1/20 | 0.39 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.39 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15055390 | 0.79 | ALDH1A1 (0.46) | ALDH1A1NR3C1L3MBTL1KEAP1PTGS1 | |
| SCHEMBL23703126 | 0.78 | NR3C1 (0.56) | ALDH1A1NR3C1PGRNR3C2AR | |
| SCHEMBL7160434 | 0.78 | NR3C1 (0.43) | ALDH1A1NR3C1PGRNR3C2AR | |
| SCHEMBL26697138 | 0.77 | NPC1 (0.48) | ALDH1A1L3MBTL1KMT2A | |
| SCHEMBL30526897 | 0.76 | KMT2A (0.56) | ALDH1A1SLC22A12L3MBTL1KMT2A | |
| SCHEMBL2350815 | 0.76 | KMT2A (0.56) | ALDH1A1SLC22A12L3MBTL1KMT2A | |
| SCHEMBL4157469 | 0.73 | SLC22A12 (0.50) | ALDH1A1SLC22A12PTGS1KMT2A | |
| SCHEMBL3970765 | 0.72 | NR3C1 (0.81) | NR3C1PGRNR3C2AR | |
| SCHEMBL13172655 | 0.72 | P2RX7 (0.45) | — | |
| SCHEMBL31500466 | 0.71 | SLC22A12 (0.49) | ALDH1A1NR3C1SLC22A12KEAP1PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2793873-A1 | BENZYL SULFONAMIDE DERIVATIVES AS RORc MODULATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-10-29 | — | — | EP | disclosed |
| EP-2794584-A1 | BENZYL SULFONAMIDE DERIVATIVES AS RORc MODULATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-10-29 | — | — | EP | disclosed |
| WO-2013092941-A1 | BENZYL SULFONAMIDE DERIVATIVES AS RORc MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-06-27 | — | — | WO | disclosed |
| WO-2013092939-A1 | BENZYL SULFONAMIDE DERIVATIVES AS RORc MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-06-27 | — | — | WO | disclosed |