Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | FPR1 | P21462 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4250189 | 0.84 | RAB9A (0.50) | NPC1RAB9ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL4622869 | 0.80 | L3MBTL1 (0.56) | SMN1; SMN2ALDH1A1LMNAMAPTL3MBTL1 | |
| SCHEMBL15055355 | 0.77 | ALDH1A1 (0.47) | ALDH1A1L3MBTL1KMT2A | |
| SCHEMBL2491853 | 0.75 | LMNA (0.66) | NPC1RAB9ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL6830332 | 0.74 | L3MBTL1 (0.49) | NPC1RAB9ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL8218714 | 0.72 | ALOX5 (0.47) | NPC1SMN1; SMN2PDPK1MAPTAKR1B1 | |
| SCHEMBL4172605 | 0.72 | L3MBTL1 (0.70) | NPC1RAB9ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL17498094 | 0.72 | NPC1 (0.49) | NPC1RAB9ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL4237309 | 0.72 | L3MBTL1 (0.56) | NPC1RAB9ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL2965399 | 0.71 | AKR1B1 (0.55) | PDPK1MAPTAKR1B1KDM1AP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023226580-A1 | PYRROLOPYRIMIDINE COMPOUND, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | 中国医学科学院药物研究所 | 2023-11-30 | — | — | WO | disclosed |