Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.43 |
| ▸ | CARM1 | Q86X55 | 3/20 | 0.43 |
| ▸ | PRMT1 | Q99873 | 3/20 | 0.43 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.42 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 4/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 2/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.38 |
| ▸ | TOP2A | P11388 | 2/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28333036 | 0.96 | MRGPRX1 (0.46) | MRGPRX1CARM1PRMT1KAT2BBAZ2B | |
| SCHEMBL15057876 | 0.92 | KAT2B (0.44) | MRGPRX1CARM1PRMT1KAT2BBAZ2B | |
| SCHEMBL24460812 | 0.81 | MRGPRX1 (0.43) | MRGPRX1CARM1PRMT1KAT2BBAZ2B | |
| SCHEMBL28707530 | 0.78 | KAT2B (0.50) | KAT2BBAZ2BPDE4DPDE4APDE4B | |
| SCHEMBL30780930 | 0.77 | POLB (0.42) | PDE5APDE4DPDE4APDE4BPDE4C | |
| SCHEMBL21600821 | 0.76 | HTR1A (0.41) | MRGPRX1CARM1PRMT1KAT2BBAZ2B | |
| SCHEMBL28331542 | 0.76 | EIF4E (0.43) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL28333030 | 0.76 | EIF4E (0.51) | CARM1PRMT1PDE4DPDE4APDE4B | |
| SCHEMBL12359570 | 0.76 | SMN1; SMN2 (0.63) | SMN1; SMN2 | |
| SCHEMBL5344402 | 0.75 | MCHR1 (0.49) | MRGPRX1CARM1PRMT1HRH1PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150148311-A1 | NON-SYSTEMIC TGR5 AGONISTS | ARDELYX INC (US) | 2015-05-28 | — | — | US | disclosed |
| EP-2794576-A1 | NON-SYSTEMIC TGR5 AGONISTS | Ardelyx, Inc. (US) | 2014-10-29 | — | — | EP | disclosed |
| WO-2013096771-A1 | NON-SYSTEMIC TGR5 AGONISTS | ARDELYX, INC. (US) | 2013-06-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150148311-A1 | NON-SYSTEMIC TGR5 AGONISTS | GLP1R, GPR119, TRHR | MRGPRX1 33/4885CARM1 1171/4885PRMT1 402/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.