Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 2/20 | 0.30 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1746782 | 0.78 | MAOB (0.40) | KDM4EALDH1A1CYP2A6TSHRHSD17B10 | |
| SCHEMBL2961433 | 0.74 | TDP1 (0.37) | POLBMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL28242978 | 0.74 | VKORC1 (0.42) | PTPN1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL28268580 | 0.74 | ALDH1A1 (0.35) | KDM4EALDH1A1CYP2A6TSHRHSD17B10 | |
| SCHEMBL2094693 | 0.74 | CYP2A6 (0.35) | MEN1KMT2AKDM4EALDH1A1CYP2A6 | |
| SCHEMBL6002448 | 0.74 | ALDH1A1 (0.35) | KDM4EALDH1A1CYP2A6TSHRHSD17B10 | |
| SCHEMBL9935525 | 0.74 | TDP1 (0.35) | PTPN1POLBMEN1KMT2AKDM4E | |
| SCHEMBL9739681 | 0.74 | HTR2A (0.43) | KDM4EALDH1A1CYP2A6TSHRHSD17B10 | |
| SCHEMBL2090282 | 0.73 | MAPT (0.33) | KDM4EALDH1A1TDP1MAOB | |
| SCHEMBL27610645 | 0.73 | ACP3 (0.34) | POLBMEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11858951-B2 | Boronic acid derivatives | MERCK PATENT GMBH (DE) | 2024-01-02 | — | — | US | disclosed |
| EP-3826723-B1 | BORONIC ACID DERIVATIVES | MERCK PATENT GMBH (DE) | 2023-10-18 | — | — | EP | disclosed |
| EP-3672977-B1 | BORONIC ACID DERIVATIVES | MERCK PATENT GMBH (DE) | 2022-06-22 | — | — | EP | disclosed |
| US-20220153761-A1 | Boronic Acid Derivatives | MERCK PATENT GMBH (DE) | 2022-05-19 | — | — | US | disclosed |
| US-11274109-B2 | Boronic acid derivatives | MERCK PATENT GMBH (DE) | 2022-03-15 | — | — | US | disclosed |
| US-20210317145-A1 | Boronic Acid Derivatives | MERCK PATENT GMBH (DE) | 2021-10-14 | — | — | US | disclosed |
| EP-3826723-A1 | BORONIC ACID DERIVATIVES | Merck Patent GmbH (DE) | 2021-06-02 | — | — | EP | disclosed |
| EP-3201207-B1 | BORONIC ACID DERIVATIVES | MERCK PATENT GMBH (DE) | 2021-02-24 | — | — | EP | disclosed |
| US-20200354382-A1 | Boronic Acid Derivatives | MERCK PATENT GMBH (DE) | 2020-11-12 | — | — | US | disclosed |
| EP-3672977-A1 | BORONIC ACID DERIVATIVES | Merck Patent GmbH (DE) | 2020-07-01 | — | — | EP | disclosed |
| EP-3201207-A1 | BORONIC ACID DERIVATIVES | Merck Patent GmbH (DE) | 2017-08-09 | — | — | EP | disclosed |
| EP-3201206-A1 | BORONIC ACID DERIVATIVES | Merck Patent GmbH (DE) | 2017-08-09 | — | — | EP | disclosed |
| EP-3201205-A1 | BORONIC ACID DERIVATIVES | Merck Patent GmbH (DE) | 2017-08-09 | — | — | EP | disclosed |
| US-9688702-B2 | Alpha-amino boronic acid derivatives, selective immunoproteasome inhibitors | ARES TRADING (CH) | 2017-06-27 | — | — | US | disclosed |
| WO-2016050358-A1 | BORONIC ACID DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-04-07 | — | — | WO | disclosed |
| WO-2016050359-A1 | BORONIC ACID DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-04-07 | — | — | WO | disclosed |
| WO-2016050355-A1 | BORONIC ACID DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-04-07 | — | — | WO | disclosed |
| US-20140364396-A1 | Alpha-amino boronic acid derivatives, selective immunoproteasome inhibitors | ARES TRADING SA (CH) | 2014-12-11 | — | — | US | disclosed |
| EP-2793900-A1 | ALPHA-AMINO BORONIC ACID DERIVATIVES, SELECTIVE IMMUNOPROTEASOME INHIBITORS | Ares Trading S.A. (CH) | 2014-10-29 | — | — | EP | disclosed |
| WO-2013092979-A1 | ALPHA-AMINO BORONIC ACID DERIVATIVES, SELECTIVE IMMUNOPROTEASOME INHIBITORS | ARES TRADING S.A. (CH) | 2013-06-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210317145-A1 | Boronic Acid Derivatives | PSMB7, PSMA7, BRD7 | PTPN1 2194/4885POLB 792/4885MEN1 993/4885 |
| US-20220153761-A1 | Boronic Acid Derivatives | PSMB7, PSMA7, BRD7 | PTPN1 2012/4885POLB 662/4885MEN1 1316/4885 |
| US-11274109-B2 | Boronic acid derivatives | PSMB7, PSMA7, BRD7 | PTPN1 2011/4885POLB 654/4885MEN1 1323/4885 |
| US-20140364396-A1 | Alpha-amino boronic acid derivatives, selective immunoproteasome inhibitors | PSMB7, PSMA7, PSMB1 | PTPN1 1720/4885POLB 554/4885MEN1 2160/4885 |
| US-11858951-B2 | Boronic acid derivatives | PSMB7, PSMA7, BRD7 | PTPN1 2012/4885POLB 662/4885MEN1 1316/4885 |
| US-20200354382-A1 | Boronic Acid Derivatives | PSMB7, PSMA7, BRD7 | PTPN1 2011/4885POLB 654/4885MEN1 1323/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.