SCHEMBL15059660

SCHEMBL15059660

CN(C)c1cc2c(c3ccccc13)C(=O)NC2=O

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 5/20 0.44
TDP1 Q9NUW8 3/20 0.42
RET P07949 2/20 0.42
GSK3B P49841 5/20 0.41
CHEK1 O14757 1/20 0.41
NEK2 P51955 1/20 0.41
LIMK1 P53667 1/20 0.41
DYRK1A Q13627 1/20 0.41
CLK4 Q9HAZ1 1/20 0.41
EGFR P00533 2/20 0.40
SRC P12931 1/20 0.40
CDK4 P11802 4/20 0.40
CCND1 P24385 4/20 0.40
CCNA2 P20248 2/20 0.40
CDK2 P24941 2/20 0.40
CCNA1 P78396 1/20 0.40
FLT3 P36888 1/20 0.39
MAPT P10636 3/20 0.38
ALDH1A1 P00352 2/20 0.38
L3MBTL1 Q9Y468 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4210732 0.83 PARP1 (0.42) PARP1TDP1GSK3BCHEK1EGFR
SCHEMBL8637609 0.75 PARP1 (0.42) PARP1TDP1GSK3BEGFRSRC
SCHEMBL9006264 0.75 EGFR (0.46) PARP1TDP1GSK3BEGFRSRC
SCHEMBL3501736 0.75 TDP1 (0.39) TDP1RETCHEK1NEK2LIMK1
Ethane SCHEMBL11238275 0.75 PARP1 (0.49) PARP1TDP1GSK3BCHEK1CDK4
SCHEMBL10396747 0.74 CHEK1 (0.36) PARP1TDP1GSK3BCHEK1CDK4
SCHEMBL7896263 0.74 PPOX (0.46) PARP1TDP1GSK3BCHEK1CDK4
SCHEMBL2114118 0.74 GSK3B (0.57) PARP1TDP1GSK3BCHEK1CDK4
SCHEMBL338831 0.74 PARP1 (0.51) PARP1TDP1GSK3BCHEK1EGFR
SCHEMBL11248196 0.74 GSK3B (0.45) PARP1GSK3BCHEK1EGFRCDK4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9879300-B2 Method and array for identifying histone-code-related analytes UVic Industry Partnerships (CA) 2018-01-30 US claimed
US-20140357503-A1 METHOD AND ARRAY FOR IDENTIFYING HISTONE-CODE-RELATED ANALYTES UVIC INDUSTRY PARTNERSHIPS INC. (CA) 2014-12-04 US claimed
WO-2013091074-A1 METHOD AND ARRAY FOR IDENTIFYING HISTONE-CODE-RELATED ANALYTES UVIC INDUSTRY PARTNERSHIPS INC. (CA) 2013-06-27 WO claimed
US-9879300-B2 Method and array for identifying histone-code-related analytes UVic Industry Partnerships (CA) 2018-01-30 US disclosed
US-20140357503-A1 METHOD AND ARRAY FOR IDENTIFYING HISTONE-CODE-RELATED ANALYTES UVIC INDUSTRY PARTNERSHIPS INC. (CA) 2014-12-04 US disclosed
WO-2013091074-A1 METHOD AND ARRAY FOR IDENTIFYING HISTONE-CODE-RELATED ANALYTES UVIC INDUSTRY PARTNERSHIPS INC. (CA) 2013-06-27 WO disclosed