SCHEMBL1505987

SCHEMBL1505987

Fc1ccc([C@@H]2CO2)cc1

nearest known ligand 0.56

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.56
KDM1A O60341 2/20 0.44
SLC6A2 P23975 2/20 0.43
HTR2A P28223 2/20 0.43
HTR2C P28335 2/20 0.43
SLC6A4 P31645 2/20 0.43
HTR2B P41595 2/20 0.43
SLC6A3 Q01959 2/20 0.43
MAOB P27338 5/20 0.42
ATM Q13315 1/20 0.41
FADS1 O60427 2/20 0.41
CYP19A1 P11511 1/20 0.38
TDP1 Q9NUW8 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1505907 1.00 TSHR (0.56) TSHRKDM1ASLC6A2HTR2AHTR2C
SCHEMBL937356 1.00 TSHR (0.56) TSHRKDM1ASLC6A2HTR2AHTR2C
SCHEMBL46155 0.86 TSHR (0.72) TSHR
SCHEMBL16422345 0.81 KDM1A (0.48) TSHRKDM1ASLC6A2HTR2AHTR2C
SCHEMBL21353917 0.81 KDM1A (0.39) TSHRKDM1ASLC6A2HTR2AHTR2C
SCHEMBL21363715 0.81 KDM1A (0.39) TSHRKDM1ASLC6A2HTR2AHTR2C
SCHEMBL21353919 0.81 KDM1A (0.39) TSHRKDM1ASLC6A2HTR2AHTR2C
SCHEMBL21393372 0.81 KDM1A (0.39) TSHRKDM1ASLC6A2HTR2AHTR2C
SCHEMBL16423075 0.81 KDM1A (0.48) TSHRKDM1ASLC6A2HTR2AHTR2C
SCHEMBL16422344 0.81 KDM1A (0.48) TSHRKDM1ASLC6A2HTR2AHTR2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119662578-A Styrene monooxygenase combined mutant and application thereof 中国科学院成都生物研究所 2025-03-21 CN claimed
CN-115927276-B Halohydrin dehalogenase mutant and application thereof in synthesis of chiral oxazolidinone 中国科学院天津工业生物技术研究所 2024-08-27 CN claimed
WO-2022093797-A1 FUNCTIONAL EPOXIDES IN CATALYST-BASED ELECTROLYTE COMPOSITIONS FOR LI-ION BATTERIES ENEVATE CORPORATION (US) 2022-05-05 WO claimed
CN-119662578-A Styrene monooxygenase combined mutant and application thereof 中国科学院成都生物研究所 2025-03-21 CN disclosed
CN-115927276-B Halohydrin dehalogenase mutant and application thereof in synthesis of chiral oxazolidinone 中国科学院天津工业生物技术研究所 2024-08-27 CN disclosed
EP-4252848-A2 OXYSTEROLS AND METHODS OF USE THEREOF Sage Therapeutics, Inc. (US) 2023-10-04 EP disclosed
US-11710854-B2 Functional epoxides in catalyst-based electrolyte compositions for Li-ion batteries ENEVATE CORPORATION (US) 2023-07-25 US disclosed
EP-3529257-B1 OXYSTEROLS AND METHODS OF USE THEREOF SAGE THERAPEUTICS INC (US) 2023-05-10 EP disclosed
CN-115927276-A Halogen alcohol dehalogenase mutant and application thereof in synthesizing chiral oxazolidinone 中国科学院天津工业生物技术研究所 2023-04-07 CN disclosed
CN-113106139-B Method for preparing chiral organic compound by catalyzing styrene and derivatives thereof 中国科学院青岛生物能源与过程研究所 2022-07-26 CN disclosed
WO-2022093797-A1 FUNCTIONAL EPOXIDES IN CATALYST-BASED ELECTROLYTE COMPOSITIONS FOR LI-ION BATTERIES ENEVATE CORPORATION (US) 2022-05-05 WO disclosed
WO-2009005646-A2 SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS SCHERING CORPORATION (US) 2009-01-08 WO disclosed
US-20080182991-A1 N- AND O-SUBSTITUED 4-[2-(DIPHENYLMETHOXY)-ETHYL]-1-[(PHENYL)METHYL]PIPERIDINE ANALOGS AND METHODS OF TREATING CNS DISORDERS THEREWITH WAYNE STATE UNIVERSITY (US) 2008-07-31 US disclosed
EP-1910320-A2 INTERMEDIATE COMPOUND FOR SYNTHESIZING PHARMACEUTICAL AGENT AND PRODUCTION METHOD THEREOF Mitsubishi Tanabe Pharma Corporation (JP) 2008-04-16 EP disclosed
WO-2007011065-A2 INTERMEDIATE COMPOUND FOR SYNTHESIZING PHARMACEUTICAL AGENT AND PRODUCTION METHOD THEREOF MITSUBISHI TANABE PHARMA CORPORATION (JP) 2007-01-25 WO disclosed
US-7153971-B2 Contacting a carbohydrate with an amine to produce amino tetrahydroxy carbohydrate, protecting two hydroxy groups of tetrahydroxy carbohydrate, forming hydroxy heterocyclic-spiro moiety by reacting with activated carbonate, oxidizing OH COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) 2006-12-26 US disclosed
EP-1317460-A4 COMPOUNDS CONTAINING OXAZOLIDINONE MOIETY AND USES THEREOF UNIV COLORADO STATE RES FOUND (US) 2005-04-20 EP disclosed
US-20040039209-A1 Compounds containing oxazolidinone moiety and uses thereof NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR 2004-02-26 US disclosed
EP-1317460-A1 COMPOUNDS CONTAINING OXAZOLIDINONE MOIETY AND USES THEREOF COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) 2003-06-11 EP disclosed
WO-2002018391-A1 COMPOUNDS CONTAINING OXAZOLIDINONE MOIETY AND USES THEREOF COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) 2002-03-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080182991-A1 N- AND O-SUBSTITUED 4-[2-(DIPHENYLMETHOXY)-ETHYL]-1-[(PHENYL)METHYL]PIPERIDINE ANALOGS AND METHODS OF TREATING CNS DISORDERS THEREWITH SLC6A3, SLC6A2, PNMT TSHR 623/4885KDM1A 2399/4885SLC6A2 2/4885
US-20040039209-A1 Compounds containing oxazolidinone moiety and uses thereof OXER1, OXA1L, AOX1 TSHR 4087/4885KDM1A 1928/4885SLC6A2 4880/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.