Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 5/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CASR | P41180 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15060528 | 0.81 | CASR (0.38) | RXRAGRIN1GRIN2BFLT3GSK3B | |
| SCHEMBL10262760 | 0.77 | ALDH1A1 (0.55) | TSHRFLT3GSK3BTDP1ADORA3 | |
| SCHEMBL12375939 | 0.76 | CASR (0.55) | TSHRCASR | |
| SCHEMBL20001815 | 0.75 | RXRA (0.39) | RXRAGRIN1GRIN2BTSHRELANE | |
| SCHEMBL15352617 | 0.74 | ALDH1A1 (0.43) | TSHRFLT3GSK3BTDP1ADORA3 | |
| SCHEMBL29571936 | 0.74 | ADORA3 (0.44) | TSHRFLT3GSK3BTDP1ADORA3 | |
| SCHEMBL5958591 | 0.74 | ADORA3 (0.44) | TSHRFLT3GSK3BTDP1ADORA3 | |
| SCHEMBL21141881 | 0.71 | KMT2A (0.53) | TSHRFLT3GSK3BADORA3ADORA2A | |
| SCHEMBL10160816 | 0.70 | KDM5A (0.35) | ALDH1A1CASR | |
| SCHEMBL9965961 | 0.70 | MPO (0.46) | ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8471024-B2 | Tetrahydrofuropyridones | MERCK SHARP & DOHME, CORP. (US) | 2013-06-25 | — | — | US | disclosed |