Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 11/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2005111 | 0.92 | PLA2G2A (0.57) | PLA2G2AALDH1A1PKMTSHRPLA2G1B | |
| SCHEMBL2002769 | 0.92 | PLA2G2A (0.52) | PLA2G2AALDH1A1PKMTSHRPLA2G1B | |
| SCHEMBL2006942 | 0.91 | PLA2G2A (0.50) | PLA2G2AALDH1A1PKMTSHRPLA2G1B | |
| SCHEMBL2006756 | 0.89 | PTGS2 (0.51) | PLA2G2AALDH1A1TSHRPLA2G1BKMT2A | |
| SCHEMBL3003525 | 0.87 | PLA2G2A (0.47) | PLA2G2AALDH1A1PKMTSHRPLA2G1B | |
| SCHEMBL2002529 | 0.85 | PLA2G2A (0.43) | PLA2G2AALDH1A1PKMTSHRPLA2G1B | |
| SCHEMBL2006833 | 0.84 | PLA2G2A (0.44) | PLA2G2AALDH1A1PKMTSHRPLA2G1B | |
| SCHEMBL2005823 | 0.82 | ALDH1A1 (0.52) | PLA2G2AALDH1A1PKMTSHRPLA2G1B | |
| SCHEMBL2002690 | 0.82 | FAAH (0.50) | PLA2G2AALDH1A1PKMTSHRMEN1 | |
| SCHEMBL2002857 | 0.82 | ALDH1A1 (0.50) | PLA2G2AALDH1A1PKMTSHRPLA2G1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2610244-A1 | Indole compounds | Ironwood Pharmaceuticals, Inc. (US) | 2013-07-03 | — | — | EP | disclosed |