Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAC1 | P63000 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 11/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | KDM1A | O60341 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 6/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22650914 | 0.91 | RAC1 (0.51) | RAC1MAPTMAPK1HTTPOLB | |
| SCHEMBL20945450 | 0.84 | MAPT (0.57) | RAC1MAPTMAPK1HTTPOLB | |
| SCHEMBL20945473 | 0.81 | RAC1 (0.69) | RAC1MAPTMAPK1HTTPOLB | |
| SCHEMBL25179738 | 0.79 | NPSR1 (0.68) | MAPTMAPK1HTTPOLBTSHR | |
| SCHEMBL20966330 | 0.79 | RAC1 (0.67) | RAC1MAPTMAPK1HTTPOLB | |
| SCHEMBL16229866 | 0.77 | RAC1 (0.39) | RAC1MAPTMAPK1HTTPOLB | |
| SCHEMBL29920559 | 0.77 | RAC1 (0.55) | RAC1MAPTMAPK1HTTPOLB | |
| SCHEMBL20966336 | 0.77 | RAC1 (0.55) | RAC1MAPTMAPK1HTTPOLB | |
| SCHEMBL20945474 | 0.76 | RAC1 (0.63) | RAC1MAPTMAPK1HTTPOLB | |
| SCHEMBL2287907 | 0.76 | NPSR1 (0.63) | MAPTMAPK1HTTPOLBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8884006-B2 | Small-molecule inhibitors of Rac1 in metastatic breast cancer | UNIVERSITY OF PUERTO RICO (US) | 2014-11-11 | — | — | US | claimed |
| US-20130172552-A1 | Novel Small-Molecule Inhibitors of Rac1 in Metastatic Breast Cancer | UNIVERSITY OF PUERTO RICO (US) | 2013-07-04 | — | — | US | claimed |
| US-11446299-B2 | Carbazole EHop-016 derivatives as anticancer and anti-migratory agents | UNIVERSITY OF PUERTO RICO (US) | 2022-09-20 | — | — | US | disclosed |
| US-20200352941-A1 | NOVEL CARBAZOLE EHOP-016 DERIVATIVES AS ANTI-CANCER AND ANTI-MIGRATORY AGENTS | UNIV PUERTO RICO (US) | 2020-11-12 | — | — | US | disclosed |
| US-10729689-B2 | Carbazole EHop-016 derivatives as anti-cancer and anti-migratory agents | UNIVERSITY OF PUERTO RICO (US) | 2020-08-04 | — | — | US | disclosed |
| US-20190125746-A1 | NOVEL CARBAZOLE EHOP-016 DERIVATIVES AS ANTI-CANCER AND ANTI-MIGRATORY AGENTS | UNIVERSITY OF PUERTO RICO (PR) | 2019-05-02 | — | — | US | disclosed |
| US-9278956-B1 | Small-molecule inhibitors of Rac1 in metastatic cancer cells | UNIVERSITY OF PUERTO RICO (US) | 2016-03-08 | — | — | US | disclosed |
| US-8884006-B2 | Small-molecule inhibitors of Rac1 in metastatic breast cancer | UNIVERSITY OF PUERTO RICO (US) | 2014-11-11 | — | — | US | disclosed |
| US-20130172552-A1 | Novel Small-Molecule Inhibitors of Rac1 in Metastatic Breast Cancer | UNIVERSITY OF PUERTO RICO (US) | 2013-07-04 | — | — | US | disclosed |
| US-20130172552-A1 | Novel Small-Molecule Inhibitors of Rac1 in Metastatic Breast Cancer | UNIVERSITY OF PUERTO RICO (US) | 2013-07-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200352941-A1 | NOVEL CARBAZOLE EHOP-016 DERIVATIVES AS ANTI-CANCER AND ANTI-MIGRATORY AGENTS | CDC42, ARHGEF2, ARHGDIB | RAC1 6/4885MAPT 4054/4885MAPK1 395/4885 |
| US-11446299-B2 | Carbazole EHop-016 derivatives as anticancer and anti-migratory agents | CDC42, ARHGEF2, HRAS | RAC1 7/4885MAPT 3790/4885MAPK1 351/4885 |
| US-20190125746-A1 | NOVEL CARBAZOLE EHOP-016 DERIVATIVES AS ANTI-CANCER AND ANTI-MIGRATORY AGENTS | CDC42, ARHGEF2, HRAS | RAC1 5/4885MAPT 3896/4885MAPK1 482/4885 |
| US-10729689-B2 | Carbazole EHop-016 derivatives as anti-cancer and anti-migratory agents | CDC42, ARHGEF2, GDI2 | RAC1 7/4885MAPT 3908/4885MAPK1 393/4885 |
| US-20130172552-A1 | Novel Small-Molecule Inhibitors of Rac1 in Metastatic Breast Cancer | TIAM1, RAC1, CDC42 | RAC1 2/4885MAPT 3419/4885MAPK1 604/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.