SCHEMBL15065576

SCHEMBL15065576

FC(F)(F)c1cn2c[c]ccc2n1

nearest known ligand 0.45

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
SCN5A Q14524 1/20 0.45
HDAC4 P56524 2/20 0.35
MCHR1 Q99705 2/20 0.32
KDM4E B2RXH2 1/20 0.30
NPC1 O15118 1/20 0.30
ALDH1A1 P00352 1/20 0.30
POLB P06746 1/20 0.30
HPGD P15428 1/20 0.30
NFKB1 P19838 1/20 0.30
RAB9A P51151 1/20 0.30
GFER P55789 1/20 0.30
NFKB2 Q00653 1/20 0.30
RELA Q04206 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30
RCE1 Q9Y256 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL976088 0.81 MCHR1 (0.36) MCHR1KDM4ENPC1ALDH1A1RAB9A
SCHEMBL12056714 0.72 SCN5A (0.54) SCN5AMCHR1KDM4ENPC1ALDH1A1
SCHEMBL161950 0.72 RAB9A (0.49) SCN5AHDAC4KDM4ENPC1ALDH1A1
SCHEMBL974506 0.71 HDAC1 (0.33) MCHR1KDM4ENPC1ALDH1A1HPGD
SCHEMBL16346549 0.70 SCN5A (0.45) SCN5AHDAC4MCHR1KDM4ENPC1
SCHEMBL18080888 0.70 SCN5A (0.53) SCN5AHDAC4MCHR1KDM4ENPC1
SCHEMBL8812209 0.70 SCN5A (0.53) SCN5AKDM4ENPC1ALDH1A1POLB
SCHEMBL2118968 0.70 SCN5A (0.53) SCN5AHDAC4MCHR1KDM4ENPC1
SCHEMBL516957 0.70 PIK3CG (0.55) SCN5AMCHR1KDM4ENPC1ALDH1A1
SCHEMBL3782018 0.70 SCN5A (0.49) SCN5AMCHR1KDM4ENPC1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3013345-A2 COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY F. Hoffmann-La Roche AG (CH) 2016-05-04 EP claimed
WO-2014209841-A2 COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY F. HOFFMANN-LA ROCHE AG (CH) 2014-12-31 WO claimed
US-20240067646-A1 COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY HOFFMANN-LA ROCHE INC. 2024-02-29 US disclosed
US-20230310651-A1 METHODS FOR MODULATING RNA SPLICING PTC THERAPEUTICS, INC. (US) 2023-10-05 US disclosed
EP-4249472-A2 METHODS FOR MODULATING RNA SPLICING PTC Therapeutics, Inc. (US) 2023-09-27 EP disclosed
US-11753407-B2 Compounds for treating spinal muscular atrophy PTC THERAPEUTICS, INC. (US) 2023-09-12 US disclosed
US-20230272367-A1 METHODS FOR MODULATING RNA SPLICING PTC THERAPEUTICS, INC. (US) 2023-08-31 US disclosed
EP-3644996-B1 METHODS FOR TREATING HUNTINGTON'S DISEASE PTC THERAPEUTICS INC (US) 2023-07-26 EP disclosed
EP-3310169-B1 METHODS FOR MODULATING RNA SPLICING PTC THERAPEUTICS INC (US) 2023-05-17 EP disclosed
US-11602567-B2 Methods for modulating RNA splicing PTC THERAPEUTICS, INC. (US) 2023-03-14 US disclosed
EP-3082820-B1 METHODS FOR MODULATING THE AMOUNT OF RNA TRANSCRIPTS PTC THERAPEUTICS INC (US) 2022-07-20 EP disclosed
WO-2014209841-A2 COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY F. HOFFMANN-LA ROCHE AG (CH) 2014-12-31 WO disclosed
EP-2812004-A2 COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY PTC Therapeutics, Inc. (US) 2014-12-17 EP disclosed
EP-2809322-A1 COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY PTC Therapeutics, Inc. (US) 2014-12-10 EP disclosed
EP-2797592-A1 COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY PTC Therapeutics, Inc. (US) 2014-11-05 EP disclosed
WO-2013142236-A1 COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY PTC THERAPEUTICS, INC. (US) 2013-09-26 WO disclosed
WO-2013130689-A1 COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY PTC THERAPEUTICS, INC. (US) 2013-09-06 WO disclosed
WO-2013119916-A2 COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY PTC THERAPEUTICS, INC. (US) 2013-08-15 WO disclosed
WO-2013112788-A1 COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY PTC THERAPEUTICS, INC. (US) 2013-08-01 WO disclosed
WO-2013101974-A1 COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY PTC THERAPEUTICS, INC. (US) 2013-07-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240067646-A1 COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY SMN1; SMN2, CPT1B, GYS1 SCN5A 1924/4885HDAC4 168/4885MCHR1 3009/4885
US-20230272367-A1 METHODS FOR MODULATING RNA SPLICING RBM17, SNRPE, HNRNPM SCN5A 2427/4885HDAC4 1353/4885MCHR1 3231/4885
US-11602567-B2 Methods for modulating RNA splicing RBM17, SNRPE, RBM3 SCN5A 2560/4885HDAC4 1313/4885MCHR1 3171/4885
US-20230310651-A1 METHODS FOR MODULATING RNA SPLICING RBM17, SNRPE, RBM3 SCN5A 2560/4885HDAC4 1313/4885MCHR1 3171/4885
US-11753407-B2 Compounds for treating spinal muscular atrophy SMN1; SMN2, CPT1B, GYS1 SCN5A 1197/4885HDAC4 23/4885MCHR1 2891/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.