SCHEMBL15068565

SCHEMBL15068565

c1ccc(OCn2cnc3ccccc32)cc1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.71
SMN1; SMN2 Q16637 8/20 0.67
LMNA P02545 4/20 0.67
TSHR P16473 2/20 0.67
ALOX15 P16050 1/20 0.67
AGER Q15109 1/20 0.61
TDP1 Q9NUW8 1/20 0.61
CYP11B1 P15538 3/20 0.59
CYP11B2 P19099 3/20 0.59
TNF P01375 1/20 0.59
LTA4H P09960 1/20 0.56
HTT P42858 4/20 0.56
EGLN3 Q9H6Z9 1/20 0.53
NPSR1 Q6W5P4 1/20 0.52
POLB P06746 1/20 0.52
MAPT P10636 1/20 0.52
MEN1 O00255 1/20 0.51
KMT2A Q03164 1/20 0.51
MAPK1 P28482 1/20 0.50
USP2 O75604 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9427745 0.94 L3MBTL1 (0.63) L3MBTL1SMN1; SMN2LMNATSHRALOX15
SCHEMBL4056785 0.87 L3MBTL1 (0.55) L3MBTL1SMN1; SMN2LMNATSHRALOX15
SCHEMBL15552180 0.84 L3MBTL1 (0.52) L3MBTL1SMN1; SMN2LMNATSHRALOX15
SCHEMBL3067924 0.83 TDP1 (0.68) L3MBTL1SMN1; SMN2LMNATSHRALOX15
SCHEMBL2640498 0.80 TDP1 (0.63) L3MBTL1SMN1; SMN2LMNATSHRALOX15
SCHEMBL1623128 0.78 AGER (0.64) L3MBTL1SMN1; SMN2LMNATSHRALOX15
SCHEMBL7138052 0.78 L3MBTL1 (0.88) L3MBTL1SMN1; SMN2LMNATSHRALOX15
SCHEMBL9670554 0.77 TDP1 (0.59) L3MBTL1SMN1; SMN2LMNATSHRALOX15
SCHEMBL7136196 0.77 SMN1; SMN2 (0.81) L3MBTL1SMN1; SMN2LMNATSHRALOX15
SCHEMBL16603995 0.77 AGER (1.00) L3MBTL1SMN1; SMN2LMNATSHRALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2809656-A2 BENZIMIDAZOLE DERIVATIVES AS SELECTIVE BLOCKERS OF PERSISTENT SODIUM CURRENT ALLERGAN, INC. (US) 2014-12-10 EP disclosed
WO-2013101911-A2 BENZIMIDAZOLE DERIVATIVES AS SELECTIVE BLOCKERS OF PERSISTENT SODIUM CURRENT ALLERGAN, INC. (US) 2013-07-04 WO disclosed