Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.58 |
| ▸ | LMNA | P02545 | 6/20 | 0.58 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.53 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.53 |
| ▸ | TNF | P01375 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 5/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | STAT3 | P40763 | 1/20 | 0.48 |
| ▸ | APAF1 | O14727 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3067924 | 0.89 | TDP1 (0.68) | TDP1SMN1; SMN2LMNACYP11B1CYP11B2 | |
| SCHEMBL1026457 | 0.83 | SMN1; SMN2 (0.79) | TDP1SMN1; SMN2LMNAHTTL3MBTL1 | |
| SCHEMBL2640498 | 0.82 | TDP1 (0.63) | TDP1SMN1; SMN2LMNACYP11B1CYP11B2 | |
| SCHEMBL28299452 | 0.82 | SMN1; SMN2 (0.62) | TDP1SMN1; SMN2LMNACYP11B1CYP11B2 | |
| SCHEMBL5388791 | 0.81 | SMN1; SMN2 (0.85) | TDP1SMN1; SMN2LMNAHTTL3MBTL1 | |
| SCHEMBL2357255 | 0.81 | SMN1; SMN2 (0.56) | TDP1SMN1; SMN2LMNACYP11B1CYP11B2 | |
| SCHEMBL30013328 | 0.81 | SMN1; SMN2 (0.56) | TDP1SMN1; SMN2LMNACYP11B1CYP11B2 | |
| SCHEMBL1623128 | 0.80 | AGER (0.64) | TDP1SMN1; SMN2LMNACYP11B1CYP11B2 | |
| SCHEMBL226221 | 0.80 | TDP1 (0.70) | TDP1SMN1; SMN2LMNACYP11B1CYP11B2 | |
| SCHEMBL9080800 | 0.79 | EGLN3 (0.51) | TDP1SMN1; SMN2LMNACYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0254322-B1 | BENZIMIDAZOLE DERIVATIVES | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1992-09-23 | — | — | EP | disclosed |
| US-4886803-A | CARDIOTONIC AGENTS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1989-12-12 | — | — | US | disclosed |
| EP-0254322-A1 | Benzimidazole derivatives | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1988-01-27 | — | — | EP | disclosed |