Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | CTSA | P10619 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15070377 | 0.92 | GABRA1 (0.41) | PDE10AALDH1A1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL9065801 | 0.86 | GABRA1 (0.44) | PDE10AALDH1A1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL15070369 | 0.74 | CYP11B2 (0.48) | ALDH1A1MAPTRAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL15070199 | 0.73 | MEN1 (0.46) | ALDH1A1MAPTRAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL15074638 | 0.70 | NSD3 (0.49) | PDE10ACDC7ALDH1A1CSNK1A1GSK3B | |
| SCHEMBL21333215 | 0.70 | NOTUM (0.48) | CTSAGRM5ALDH1A1MAPT | |
| SCHEMBL31472663 | 0.70 | NOTUM (0.48) | CTSAGRM5ALDH1A1MAPT | |
| SCHEMBL4581815 | 0.70 | KDM4C (0.55) | PDE10ACTSAKDM4CGRM5ALDH1A1 | |
| SCHEMBL8212224 | 0.69 | NSD3 (0.41) | PDE10AGRM5ALDH1A1SMN1; SMN2MAPK14 | |
| SCHEMBL15070203 | 0.68 | GABRA1 (0.47) | ALDH1A1MAPTRAB9AKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130165483-A1 | HETEROARYLS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130165483-A1 | HETEROARYLS AND USES THEREOF | PIK3R5, PIK3R4, PIK3C2B | PDE10A 3390/4885CDC7 793/4885CTSA 996/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.