Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.50 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.48 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | TRPC3 | Q13507 | 4/20 | 0.47 |
| ▸ | TRPC6 | Q9Y210 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2517603 | 0.86 | RIPK1 (0.51) | RIPK1ALDH1A1PKML3MBTL1POLB | |
| SCHEMBL28471941 | 0.82 | RIPK1 (0.48) | RIPK1ALDH1A1PKML3MBTL1POLB | |
| SCHEMBL3329035 | 0.82 | KDM4E (0.50) | RIPK1NPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL13974870 | 0.81 | NAMPT (0.50) | RIPK1NPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL2722252 | 0.79 | POLB (0.48) | RIPK1ALDH1A1PKMPOLBKMT2A | |
| SCHEMBL471101 | 0.78 | HPGD (0.33) | RIPK1APOBEC3AAPOBEC3GACHETRPC3 | |
| SCHEMBL2310817 | 0.78 | SMN1; SMN2 (0.53) | NPC1RAB9ASMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL13532859 | 0.78 | KDM4E (0.46) | RIPK1HPGDALDH1A1PKML3MBTL1 | |
| SCHEMBL25416911 | 0.77 | PKM (0.45) | RIPK1ALDH1A1TP53PKMPOLB | |
| SCHEMBL3337133 | 0.76 | KDM4E (0.47) | RIPK1ALDH1A1PKMPOLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107827841-A | Trifluoromethyl alcohol as Ror γ t conditioning agents | 詹森药业有限公司 | 2018-03-23 | — | — | CN | disclosed |
| CN-107108599-A | Trifluoromethanols as Ror gamma t modulators | 詹森药业有限公司 | 2017-08-29 | — | — | CN | disclosed |
| US-9181183-B2 | Prostaglandin D synthase inhibitory piperidine compounds | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2015-11-10 | — | — | US | disclosed |
| US-9181183-B2 | Prostaglandin D synthase inhibitory piperidine compounds | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2015-11-10 | — | — | US | disclosed |
| US-20130165438-A1 | PROSTAGLANDIN D SYNTHASE INHIBITORY PIPERIDINE COMPOUNDS | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2013-06-27 | — | — | US | disclosed |
| US-20130165438-A1 | PROSTAGLANDIN D SYNTHASE INHIBITORY PIPERIDINE COMPOUNDS | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2013-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130165438-A1 | PROSTAGLANDIN D SYNTHASE INHIBITORY PIPERIDINE COMPOUNDS | PTGIS, PTGS1, PTGDR | RIPK1 4641/4885APOBEC3A 2650/4885APOBEC3G 2109/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.