Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 4/20 | 0.35 |
| ▸ | MLYCD | O95822 | 3/20 | 0.35 |
| ▸ | IDO1 | P14902 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17736703 | 0.83 | ALDH1A1 (0.39) | ALDH1A1EPHX2SMN1; SMN2KDM4ERECQL | |
| SCHEMBL4397210 | 0.82 | KDM4E (0.41) | ALDH1A1EPHX2ROCK1KDM4ETDP1 | |
| SCHEMBL19026668 | 0.80 | MLYCD (0.39) | ALDH1A1EPHX2ROCK1SMN1; SMN2KDM4E | |
| SCHEMBL13664090 | 0.80 | FGFR1 (0.38) | ALDH1A1EPHX2ROCK1SMN1; SMN2KDM4E | |
| SCHEMBL12199026 | 0.73 | BRD4 (0.41) | ALDH1A1SMN1; SMN2KDM4ERECQL | |
| SCHEMBL10289304 | 0.73 | ALDH1A1 (0.37) | ALDH1A1EPHX2SMN1; SMN2KDM4ERECQL | |
| SCHEMBL4657505 | 0.73 | KMT2A (0.41) | ALDH1A1SMN1; SMN2KDM4ERECQLPOLB | |
| SCHEMBL17324778 | 0.72 | — | — | |
| SCHEMBL3175510 | 0.72 | CA1 (0.36) | ROCK1FAAH | |
| SCHEMBL10605862 | 0.71 | CYP1A2 (0.53) | ALDH1A1SMN1; SMN2TDP1RECQLIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8846927-B2 | Inhibitors of protein tyrosine kinase activity | METHYLGENE INC. (CA) | 2014-09-30 | — | — | US | disclosed |
| US-20130165477-A1 | INHIBITORS OF PROTEIN TYROSINE KINASE ACTIVITY | METHYLGENE INC. (CA) | 2013-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130165477-A1 | INHIBITORS OF PROTEIN TYROSINE KINASE ACTIVITY | HGF, ERBB2, MET | ALDH1A1 3139/4885EPHX2 2630/4885ROCK1 108/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.