Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD3 | Q9NY59 | 10/20 | 0.67 |
| ▸ | MAPT | P10636 | 9/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | HPGD | P15428 | 4/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.64 |
| ▸ | PPARG | P37231 | 1/20 | 0.64 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.64 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15075604 | 0.88 | SMPD3 (0.76) | SMPD3MAPTKDM4EALDH1A1HPGD | |
| SCHEMBL9736817 | 0.83 | MAPK13 (0.71) | MAPTKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL14059826 | 0.79 | KDM4E (1.00) | SMPD3MAPTKDM4EALDH1A1HPGD | |
| SCHEMBL244059 | 0.77 | SMPD3 (0.80) | SMPD3MAPTKDM4EALDH1A1HPGD | |
| SCHEMBL30111673 | 0.76 | MAPT (0.67) | SMPD3MAPTKDM4EALDH1A1HPGD | |
| SCHEMBL29590048 | 0.74 | CYP2A6 (1.00) | MAPTKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL158705 | 0.74 | CYP2A6 (1.00) | MAPTKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL22291134 | 0.73 | SMPD3 (1.00) | SMPD3MAPTKDM4EALDH1A1HPGD | |
| SCHEMBL28402826 | 0.73 | NPY5R (0.88) | SMPD3MAPTKDM4EALDH1A1HPGD | |
| SCHEMBL15075610 | 0.73 | MAPK13 (0.77) | SMPD3MAPTKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130165472-A1 | HETEROARYLS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130165472-A1 | HETEROARYLS AND USES THEREOF | PIK3R4, VPS4B, PIK3C2A | SMPD3 1402/4885MAPT 4467/4885KDM4E 1283/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.