Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12301168 | 0.85 | CA12 (0.47) | SYKMAPTSMN1; SMN2CA12CA1 | |
| SCHEMBL15076166 | 0.83 | MAPT (0.45) | SYKCYP11B1CYP11B2KDM4EMAPT | |
| SCHEMBL17955464 | 0.82 | ALDH1A1 (0.48) | SYKCYP11B1CYP11B2KDM4EMAPT | |
| SCHEMBL2558141 | 0.80 | SYK (0.44) | SYKCYP11B1CYP11B2KDM4EMAPT | |
| SCHEMBL8891479 | 0.79 | KDM4E (0.51) | SYKKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL8890306 | 0.77 | L3MBTL1 (0.50) | KDM4EMAPTRAB9AHTTALDH1A1 | |
| SCHEMBL14015 | 0.73 | FFAR1 (0.44) | KDM4ESMN1; SMN2FFAR1FFAR4LMNA | |
| SCHEMBL13069271 | 0.73 | FFAR1 (0.47) | KDM4EMAPTSMN1; SMN2FFAR1FFAR4 | |
| SCHEMBL5217886 | 0.72 | HRH1 (0.41) | SYKKDM4EMAPTSMN1; SMN2CA12 | |
| SCHEMBL17955463 | 0.72 | NPSR1 (0.53) | KDM4ECA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2794608-B1 | TETRAAZA-CYCLOPENTA[A]INDENYL AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS | MERCK PATENT GMBH (DE) | 2016-09-14 | — | — | EP | disclosed |
| EP-2607364-A1 | Tetraaza-cyclopenta[a]indenyl and their use as positive allosteric modulators | Ares Trading S.A. (CH) | 2013-06-26 | — | — | EP | disclosed |