Phenylalanine

Phenylalanine

SCHEMBL1507755

N[C@@H](Cc1ccccc1)C(=O)O.Nc1ccccc1N

nearest known ligand 0.85

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC7A5 Q01650 4/20 0.85
PTGS1 P23219 2/20 0.85
ALPI P09923 1/20 0.85
PKM P14618 1/20 0.85
XIAP P98170 1/20 0.85
SLC1A3 P43003 2/20 0.61
SLC1A2 P43004 2/20 0.61
SLC1A1 P43005 2/20 0.61
SLC15A1 P46059 1/20 0.56
CYP1A2 P05177 1/20 0.53
LTA4H P09960 1/20 0.53
GRIA2 P42262 1/20 0.53
KYNU Q16719 2/20 0.51
KDM4E B2RXH2 1/20 0.51
USP2 O75604 1/20 0.51
EGFR P00533 1/20 0.51
LCK P06239 1/20 0.51
FYN P06241 1/20 0.51
ADORA3 P0DMS8 1/20 0.51
ALOX15 P16050 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dl-Phenylalanine SCHEMBL29069525 1.00 SLC7A5 (0.85) SLC7A5PTGS1ALPIPKMXIAP
Dl-Phenylalanine SCHEMBL1449124 0.92 SLC7A5 (1.00) SLC7A5PTGS1ALPIPKMXIAP
Phenylalanine SCHEMBL16398197 0.92 SLC7A5 (1.00) SLC7A5PTGS1ALPIPKMXIAP
Dl-Phenylalanine SCHEMBL15671104 0.92 SLC7A5 (1.00) SLC7A5PTGS1ALPIPKMXIAP
Dl-Phenylalanine SCHEMBL385804 0.92 SLC7A5 (1.00) SLC7A5PTGS1ALPIPKMXIAP
SCHEMBL23159186 0.92 SLC7A5 (1.00) SLC7A5PTGS1ALPIPKMXIAP
Dl-Phenylalanine SCHEMBL8118 0.92 SLC7A5 (1.00) SLC7A5PTGS1ALPIPKMXIAP
Dl-Phenylalanine SCHEMBL16398196 0.92 SLC7A5 (1.00) SLC7A5PTGS1ALPIPKMXIAP
Phenylalanine SCHEMBL8119 0.92 SLC7A5 (1.00) SLC7A5PTGS1ALPIPKMXIAP
D-Phenylalanine SCHEMBL837632 0.92 SLC7A5 (1.00) SLC7A5PTGS1ALPIPKMXIAP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 112 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024034685-A1 AFFIBODY MICELLE DRUG CONJUGATE 興和株式会社 2024-02-15 WO claimed
WO-2024034684-A1 NEW DRUG COMPLEX 興和株式会社 2024-02-15 WO claimed
US-20240009314-A1 COMPOSITIONS AND METHODS FOR TARGETING TUMOR-ASSOCIATED MACROPHAGES RESOLUTE SCIENCE (US) 2024-01-11 US claimed
CN-116801871-A Combination therapy 思进公司 2023-09-22 CN claimed
EP-4240415-A1 COMBINATION-THERAPY ANTIBODY DRUG CONJUGATE WITH IMMUNE CELL INHIBITOR Seagen Inc. (US) 2023-09-13 EP claimed
US-20230270877-A1 Combination Therapy SEAGEN INC. (US) 2023-08-31 US claimed
EP-4199936-A1 COMPOSITIONS AND METHODS FOR TARGETING TUMOR-ASSOCIATED MACROPHAGES Resolute Science, Inc. (US) 2023-06-28 EP claimed
WO-2022098972-A1 COMBINATION-THERAPY ANTIBODY DRUG CONJUGATE WITH IMMUNE CELL INHIBITOR SEAGEN INC. (US) 2022-05-12 WO claimed
WO-2022040580-A1 COMPOSITIONS AND METHODS FOR TARGETING TUMOR-ASSOCIATED MACROPHAGES RESOLUTE SCIENCE (US) 2022-02-24 WO claimed
EP-3903812-A1 ANTIBODY DRUG CONJUGATES (ADC) THAT BIND TO 191P4D12 PROTEINS Agensys, Inc. (US) 2021-11-03 EP claimed
US-9314538-B2 Nucleic acid molecules encoding antibody drug conjugates (ADC) that bind to 191P4D12 proteins AGENSYS, INC. (US) 2016-04-19 US claimed
CN-110352074-B Cysteine mutant antibodies for conjugation 思进股份有限公司 2024-07-16 CN disclosed
US-20240207431-A1 USE OF ANTIBODY-DRUG CONJUGATE IN COMBINATION WITH IMMUNE CHECKPOINT INHIBITOR IN TREATMENT OF UROTHELIAL CANCER REMEGEN CO LTD (CN) 2024-06-27 US disclosed
US-20240207424-A1 USE OF HER2-TARGETING ANTIBODY-DRUG CONJUGATE IN TREATMENT OF HER2-LOW EXPRESSING BREAST CANCER REMEGEN CO LTD (CN) 2024-06-27 US disclosed
US-20240182580-A1 ANTI-CD74 ANTIBODY CONJUGATES, COMPOSITIONS COMPRISING ANTI CD74 ANTIBODY CONJUGATES AND METHODS OF USING ANTI-CD74 ANTIBODY CONJUGATES SUTRO BIOPHARMA INC (US) 2024-06-06 US disclosed
EP-1594542-A4 ANTI-CD70 ANTIBODY-DRUG CONJUGATES AND THEIR USE FOR THE TREATMENT OF CANCER AND IMMUNE DISORDERS SEATTLE GENETICS INC (US) 2007-05-02 EP disclosed
US-20060233794-A1 Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders SEATTLE GENETICS, INC. (US) 2006-10-19 US disclosed
EP-1594542-A2 ANTI-CD70 ANTIBODY-DRUG CONJUGATES AND THEIR USE FOR THE TREATMENT OF CANCER AND IMMUNE DISORDERS Seattle Genetics, Inc. (US) 2005-11-16 EP disclosed
WO-2004073656-A9 ANTI-CD70 ANTIBODY-DRUG CONJUGATES AND THEIR USE FOR THE TREATMENT OF CANCER AND IMMUNE DISORDERS SEATTLE GENETICS INC (US) 2005-09-01 WO disclosed
WO-2004073656-A2 ANTI-CD70 ANTIBODY-DRUG CONJUGATES AND THEIR USE FOR THE TREATMENT OF CANCER AND IMMUNE DISORDERS SEATTLE GENETICS, INC. (US) 2004-09-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240207431-A1 USE OF ANTIBODY-DRUG CONJUGATE IN COMBINATION WITH IMMUNE CHECKPOINT INHIBITOR IN TREATMENT OF UROTHELIAL CANCER CD274, PDCD1LG2, PDCD1 SLC7A5 2424/4885PTGS1 1926/4885ALPI 2221/4885
US-20240207424-A1 USE OF HER2-TARGETING ANTIBODY-DRUG CONJUGATE IN TREATMENT OF HER2-LOW EXPRESSING BREAST CANCER ERBB2, FCGR2A, EGFR SLC7A5 309/4885PTGS1 3436/4885ALPI 3655/4885
US-20060233794-A1 Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders CD74, CD63, CD2 SLC7A5 1977/4885PTGS1 4227/4885ALPI 1497/4885
US-20230270877-A1 Combination Therapy FCGR3B, CD22, CD47 SLC7A5 4300/4885PTGS1 4594/4885ALPI 3358/4885
US-20240009314-A1 COMPOSITIONS AND METHODS FOR TARGETING TUMOR-ASSOCIATED MACROPHAGES CD47, CD68, CD14 SLC7A5 1587/4885PTGS1 3043/4885ALPI 3721/4885
US-20240182580-A1 ANTI-CD74 ANTIBODY CONJUGATES, COMPOSITIONS COMPRISING ANTI CD74 ANTIBODY CONJUGATES AND METHODS OF USING ANTI-CD74 ANTIBODY CONJUGATES CD74, CD63, CD99 SLC7A5 2691/4885PTGS1 4826/4885ALPI 1470/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.