Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 2/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | NEK2 | P51955 | 1/20 | 0.31 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | BRD2 | P25440 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12547056 | 1.00 | GRIN1 (0.35) | GRIN1GRIN2AOPRM1HTR2BSCN9A | |
| SCHEMBL24112195 | 0.94 | GRIN1 (0.34) | GRIN1GRIN2AOPRM1HTR2BSCN9A | |
| SCHEMBL20038287 | 0.92 | GRIN1 (0.37) | GRIN1GRIN2AOPRM1HTR2BPOLB | |
| SCHEMBL24242202 | 0.85 | ALDH1A1 (0.38) | GRIN1GRIN2APOLB | |
| SCHEMBL18558853 | 0.82 | LMNA (0.32) | POLBCRBN | |
| SCHEMBL31341751 | 0.82 | GRIN1 (0.38) | GRIN1GRIN2AOPRM1HTR2BPOLB | |
| SCHEMBL16625642 | 0.78 | OPRM1 (0.30) | OPRM1HTR2B | |
| SCHEMBL25876684 | 0.78 | GRIN1 (0.33) | GRIN1GRIN2AOPRM1HTR2BNEK2 | |
| SCHEMBL25876679 | 0.78 | SOS1 (0.32) | GRIN1GRIN2AOPRM1HTR2B | |
| SCHEMBL24740822 | 0.77 | INMT (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2794612-B1 | 2-(PYRIDIN-2YL)-1,7-DIAZA-SPIRO[4.4]NONANE-6-ONE COMPOUNDS AS VOLTAGE-GATED SODIUM CHANNELS MODULATORS | CONVERGENCE PHARMACEUTICALS (GB) | 2016-04-06 | — | — | EP | disclosed |
| WO-2013093497-A1 | 2 - (PYRIDIN- 2YL) - 1, 7 -DIAZA- SPIRO [4.4] NONANE- 6 -ONE COMPOUNDS AS VOLTAGE - GATED SODIUM CHANNELS MODULATORS | Convergence Pharmaceuticals Limited (GB) | 2013-06-27 | — | — | WO | disclosed |