Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.49 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | NCF1 | P14598 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26420650 | 0.86 | TLR8 (0.60) | AAK1TLR8KDM4EMAPK1NPSR1 | |
| SCHEMBL15056707 | 0.81 | PRKCZ (0.47) | — | |
| SCHEMBL15056708 | 0.81 | PRKCZ (0.47) | — | |
| SCHEMBL10157305 | 0.76 | PIK3CA (0.57) | TLR8KDM4EMAPK1NPSR1LMNA | |
| SCHEMBL30440258 | 0.76 | PIK3CA (0.57) | TLR8KDM4EMAPK1NPSR1LMNA | |
| SCHEMBL282245 | 0.76 | LMNA (0.58) | KDM4EMAPK1NPSR1LMNAHTR1A | |
| SCHEMBL29729443 | 0.76 | LMNA (0.58) | KDM4EMAPK1NPSR1LMNAHTR1A | |
| SCHEMBL2051073 | 0.75 | MAP3K14 (0.57) | TLR8KDM4EMAPK1NPSR1LMNA | |
| SCHEMBL13191354 | 0.70 | TLR8 (0.65) | TLR8KDM4EMAPK1NPSR1LMNA | |
| SCHEMBL12988592 | 0.70 | TLR8 (0.58) | TLR8KDM4EMAPK1NPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013093850-A1 | QUINOLINE DERIVATIVES | NOVARTIS AG (CH) | 2013-06-27 | — | — | WO | disclosed |