Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 8/20 | 0.69 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SGMS2 | Q8NHU3 | 9/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18211386 | 0.82 | APP (0.76) | APP | |
| SCHEMBL1507879 | 0.82 | APP (0.76) | APP | |
| SCHEMBL29375251 | 0.81 | APP (1.00) | APP | |
| SCHEMBL1614417 | 0.81 | APP (1.00) | APP | |
| SCHEMBL12268073 | 0.81 | APP (1.00) | APP | |
| SCHEMBL12317126 | 0.81 | APP (0.74) | APP | |
| SCHEMBL19154810 | 0.75 | APP (0.62) | APPTP53HPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL13052998 | 0.74 | ALDH1A1 (0.52) | TP53HPGDSMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL18806907 | 0.74 | APP (1.00) | APP | |
| SCHEMBL29680823 | 0.72 | KDM4E (0.46) | TP53HPGDSMN1; SMN2HSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2011524864-A | — | — | 2011-09-08 | — | — | JP | claimed |
| EP-2300481-A2 | NOVEL SUBSTITUTED AZABENZOXAZOLES | Merck Sharp & Dohme Corp. (US) | 2011-03-30 | — | — | EP | claimed |
| WO-2009155017-A2 | NOVEL SUBSTITUTED AZABENZOXAZOLES | MERCK & CO., INC. (US) | 2009-12-23 | — | — | WO | claimed |