Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 9/20 | 0.51 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.43 |
| ▸ | CACNA1G | O43497 | 4/20 | 0.42 |
| ▸ | CACNA1H | O95180 | 4/20 | 0.42 |
| ▸ | CACNA1I | Q9P0X4 | 4/20 | 0.42 |
| ▸ | BRS3 | P32247 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12628259 | 0.78 | TBXA2R (0.41) | BRD4SIRT1CACNA1GCACNA1HCACNA1I | |
| SCHEMBL10341454 | 0.74 | KMT2A (0.49) | BRD4SIRT1S1PR1S1PR5 | |
| SCHEMBL13632458 | 0.72 | DRD2 (0.49) | BRD4SIRT1CACNA1GCACNA1HCACNA1I | |
| SCHEMBL9043612 | 0.72 | POLB (0.46) | BRD4SIRT1S1PR1S1PR5 | |
| SCHEMBL431599 | 0.71 | MTNR1A (0.60) | BRD4SIRT1MTNR1AMTNR1BCACNA1G | |
| SCHEMBL20262221 | 0.70 | BRD4 (0.43) | BRD4SIRT1MTNR1AMTNR1BCACNA1G | |
| SCHEMBL14819922 | 0.69 | SIRT1 (0.54) | BRD4SIRT1MTNR1AMTNR1BCACNA1G | |
| SCHEMBL10928480 | 0.69 | SIRT1 (0.82) | SIRT1 | |
| SCHEMBL31581689 | 0.68 | S1PR5 (0.59) | BRD4S1PR1S1PR5 | |
| SCHEMBL16722222 | 0.68 | BRD4 (1.00) | BRD4CACNA1GCACNA1HCACNA1I |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2610244-A1 | Indole compounds | Ironwood Pharmaceuticals, Inc. (US) | 2013-07-03 | — | — | EP | disclosed |