Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.54 |
| ▸ | CACNA1I | Q9P0X4 | 13/20 | 0.48 |
| ▸ | CACNA1G | O43497 | 12/20 | 0.48 |
| ▸ | CACNA1H | O95180 | 12/20 | 0.48 |
| ▸ | BRD4 | O60885 | 3/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13632458 | 0.78 | DRD2 (0.49) | SIRT1CACNA1ICACNA1GCACNA1HBRD4 | |
| SCHEMBL30009942 | 0.74 | BRD4 (0.53) | CACNA1ICACNA1GCACNA1HBRD4 | |
| SCHEMBL14293859 | 0.71 | CACNA1G (0.56) | SIRT1CACNA1ICACNA1GCACNA1H | |
| SCHEMBL16758556 | 0.70 | SIRT1 (1.00) | SIRT1 | |
| SCHEMBL30099079 | 0.70 | NOTUM (0.41) | SIRT1CACNA1ICACNA1GCACNA1HBRD4 | |
| SCHEMBL14051402 | 0.70 | TUBB4A (0.47) | SIRT1CACNA1ICACNA1GCACNA1H | |
| SCHEMBL15083046 | 0.69 | BRD4 (0.51) | SIRT1CACNA1ICACNA1GCACNA1HBRD4 | |
| SCHEMBL28162634 | 0.69 | SIRT2 (0.55) | SIRT1CACNA1ICACNA1GCACNA1H | |
| SCHEMBL10341454 | 0.68 | KMT2A (0.49) | SIRT1BRD4 | |
| SCHEMBL27977470 | 0.68 | CACNA1G (0.46) | SIRT1CACNA1ICACNA1GCACNA1HBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2572730-A1 | METHOD FOR PREVENTION OR TREATMENT OF METABOLIC SYNDROME | Miyazaki, Toru (JP) | 2013-03-27 | — | — | EP | disclosed |