Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.43 |
| ▸ | STING1 | Q86WV6 | 8/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | WNT3A | P56704 | 4/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | ALAD | P13716 | 2/20 | 0.33 |
| ▸ | SCD | O00767 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15083062 | 0.83 | MAPK14 (0.43) | MKNK1MKNK2HDAC4MAPK14 | |
| SCHEMBL6843818 | 0.79 | TP53 (0.44) | — | |
| SCHEMBL2722584 | 0.79 | MKNK1 (0.58) | HCAR2MKNK1MKNK2HDAC4 | |
| SCHEMBL6740513 | 0.75 | ALAD (0.51) | ALAD | |
| SCHEMBL6668534 | 0.75 | ALAD (0.51) | ALAD | |
| SCHEMBL28093059 | 0.75 | CA12 (0.49) | MAPK14 | |
| SCHEMBL26613959 | 0.73 | ATR (0.43) | WNT3A | |
| SCHEMBL17208102 | 0.72 | MKNK1 (0.63) | HCAR2MKNK1MKNK2HDAC4 | |
| SCHEMBL12571313 | 0.72 | DHODH (0.45) | HCAR2MKNK1MKNK2HDAC4 | |
| SCHEMBL11000258 | 0.71 | ALPL (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8884020-B2 | Indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2014-11-11 | — | — | US | disclosed |
| EP-2610244-A1 | Indole compounds | Ironwood Pharmaceuticals, Inc. (US) | 2013-07-03 | — | — | EP | disclosed |