Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | SI | P14410 | 1/20 | 0.33 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.33 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22885533 | 0.74 | ALDH1A1 (0.34) | POLBALDH1A1TRPA1LMNAHSD17B10 | |
| SCHEMBL28614040 | 0.74 | OPRM1 (0.38) | GAA | |
| SCHEMBL26521044 | 0.73 | ALDH1A1 (0.41) | ALOX15POLBALDH1A1TRPA1LMNA | |
| SCHEMBL34461866 | 0.73 | ALOX15 (0.39) | ALOX15POLBALDH1A1LMNAHSD17B10 | |
| SCHEMBL26529108 | 0.73 | ALDH1A1 (0.41) | ALOX15POLBALDH1A1TRPA1LMNA | |
| SCHEMBL32674026 | 0.73 | ALDH1A1 (0.41) | ALOX15POLBALDH1A1TRPA1LMNA | |
| SCHEMBL12868635 | 0.73 | ALDH1A1 (0.41) | ALOX15POLBALDH1A1TRPA1LMNA | |
| SCHEMBL17479967 | 0.73 | ALDH1A1 (0.41) | ALOX15POLBALDH1A1TRPA1LMNA | |
| SCHEMBL29192006 | 0.73 | ALDH1A1 (0.37) | ALOX15POLBALDH1A1TRPA1LMNA | |
| SCHEMBL5116398 | 0.72 | ALOX15 (0.42) | ALOX15POLBALDH1A1LMNAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2797884-B1 | NEW AZETIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | BOEHRINGER INGELHEIM INT (DE) | 2016-04-13 | — | — | EP | disclosed |
| WO-2013098375-A1 | NEW AZETIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-07-04 | — | — | WO | disclosed |