Hydrochloric Acid

Hydrochloric Acid

SCHEMBL1508422

Cc1ccc([N+](C)(C)C)cc1.[Cl-]

nearest known ligand 0.55

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ACHE known ✓ P22303 9/20 0.50
TDP1 Q9NUW8 1/20 0.50
APOBEC3A P31941 1/20 0.48
APOBEC3G Q9HC16 1/20 0.48
ALDH1A1 P00352 4/20 0.38
CA1 P00915 1/20 0.38
CA2 P00918 1/20 0.38
CA7 P43166 1/20 0.38
CA9 Q16790 1/20 0.38
TSHR P16473 3/20 0.35
LMNA P02545 2/20 0.35
ALOX12 P18054 1/20 0.35
IDO1 P14902 1/20 0.33
CES2 O00748 1/20 0.33
CES1 P23141 1/20 0.33
CYP2A6 P11509 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL841700 0.97 ACHE (0.53) ACHETDP1APOBEC3AAPOBEC3GALDH1A1
SCHEMBL27385711 0.94 ACHE (0.50) ACHETDP1APOBEC3AAPOBEC3GALDH1A1
Bromide SCHEMBL8612056 0.94 ACHE (0.50) ACHETDP1APOBEC3AAPOBEC3GALDH1A1
Iodide SCHEMBL8506434 0.94 APOBEC3A (0.55) ACHETDP1APOBEC3AAPOBEC3GALDH1A1
Water SCHEMBL11594553 0.94 ACHE (0.50) ACHETDP1APOBEC3AAPOBEC3GALDH1A1
SCHEMBL13548402 0.88 ACHE (0.44) ACHETDP1APOBEC3AAPOBEC3GALDH1A1
Hydrochloric Acid SCHEMBL6368015 0.87 APOBEC3A (0.59) ACHETDP1APOBEC3AAPOBEC3GALDH1A1
SCHEMBL2489383 0.83 APOBEC3A (0.62) ACHEAPOBEC3AAPOBEC3GCA9
Hydrochloric Acid SCHEMBL29010537 0.81 ACHE (0.50) ACHETDP1ALDH1A1CA1CA2
Iodide SCHEMBL6373433 0.79 APOBEC3A (0.69) ACHEAPOBEC3AAPOBEC3GCA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2014025352-A1 FLAME RETARDANT NYLON EMPIRE TECHNOLOGY DEVELOPMENT LLC (US) 2014-02-13 WO disclosed
US-8206673-B2 Method of preparing boron-nitrogen compounds WILDCAT DISCOVERY TECHNOLOGIES (US) 2012-06-26 US disclosed
US-20110064640-A1 METHOD OF PREPARING BORON-NITROGEN COMPOUNDS WILDCAT DISCOVERY TECHNOLOGIES (US) 2011-03-17 US disclosed
EP-0269884-B1 CATALYZED ALKYLATION OF HALOPYRIDINATES IN THE ABSENCE OF ADDED ORGANIC SOLVENTS DOWELANCO (US) 1991-09-25 EP disclosed
EP-0277292-B1 ORGANIC SOLVENT-FREE PROCESS FOR PREPARING PYRIMIDINYL ORGANOPHOSPHATES THE DOW CHEMICAL COMPANY (US) 1991-05-08 EP disclosed
EP-0277292-A1 Organic solvent-free process for preparing pyrimidinyl organophosphates THE DOW CHEMICAL COMPANY (US) 1988-08-10 EP disclosed
EP-0269884-A1 Catalyzed alkylation of halopyridinates in the absence of added organic solvents DOWELANCO (US) 1988-06-08 EP disclosed
US-4701531-A Catalyzed alkylation of halopyridinates in the absence of added organic solvents THE DOW CHEMICAL COMPANY (US) 1987-10-20 US disclosed
US-4699634-A SEMIPERMEABLE MEMBRANES THE STANDARD OIL COMPANY (US) 1987-10-13 US disclosed
US-4546189-A Preparation of cyano(6-(substituted phenoxy)-2-pyridinyl)methyl esters of 3-(2,2-dihaloethenyl)-2,2-dimethylcyclopropane carboxylic acids THE DOW CHEMICAL COMPANY (US) 1985-10-08 US disclosed
US-4028439-A QUATERNARY AMMONIUM SALT AND IMIDAZOLE CATALYSTS THE DOW CHEMICAL COMPANY (US) 1977-06-07 US disclosed
US-4016225-A WITH QUATERNARY AMMONIUM SALT AND 1,4-DIAZABICYCLO(2.2.2)OCTANE CATALYST THE DOW CHEMICAL COMPANY (US) 1977-04-05 US disclosed
US-4014891-A FROM AN ALKALI METAL ARYL MERCAPTIDE AND BROMOCHLOROMETHANE IN A QUATERNARY AMMONIUM SALT THE DOW CHEMICAL COMPANY (US) 1977-03-29 US disclosed
US-4007197-A QUATERNARY AMMONIUM OR PHOSPHONIUM SALT AND TERTIARY AMINE CATALYST THE DOW CHEMICAL COMPANY (US) 1977-02-08 US disclosed
US-4001293-A Process for production of γ-halonitriles THE DOW CHEMICAL COMPANY (US) 1977-01-04 US disclosed
US-3996259-A QUATERNARY AMMONIUM OR PHOSPHONIUM SALT THE DOW CHEMICAL COMPANY (US) 1976-12-07 US disclosed
US-3992159-A Process for purification by cryogenic sublimation BELL TELEPHONE LABORATORIES, INCORPORATED (US) 1976-11-16 US disclosed
US-3974199-A Process for production of cyclopropylcyanide THE DOW CHEMICAL COMPANY (US) 1976-08-10 US disclosed
US-3972887-A QUATERNARY AMMONIUM SALT CATALYST THE DOW CHEMICAL COMPANY (US) 1976-08-03 US disclosed
US-3969360-A Catalyzed alkylation of halopyridinates THE DOW CHEMICAL COMPANY (US) 1976-07-13 US disclosed