Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 4/20 | 0.42 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.42 |
| ▸ | TUBB | P07437 | 3/20 | 0.42 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.42 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.42 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.42 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.42 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.42 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.42 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.42 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.42 |
| ▸ | TUBA1A | Q71U36 | 3/20 | 0.42 |
| ▸ | TUBA1C | Q9BQE3 | 3/20 | 0.42 |
| ▸ | TUBB6 | Q9BUF5 | 3/20 | 0.42 |
| ▸ | TUBB2B | Q9BVA1 | 3/20 | 0.42 |
| ▸ | LDHA | P00338 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL296731 | 0.81 | TUBB1 (0.64) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| Niacinamide SCHEMBL1508289 | 0.80 | MAPK1 (0.45) | KDM4EALDH1A1L3MBTL1CYP3A4 | |
| SCHEMBL28654468 | 0.79 | TUBB1 (0.48) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL28659072 | 0.78 | TUBB1 (0.47) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL13991618 | 0.74 | TUBB4A (0.61) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL1508665 | 0.72 | TUBB1 (0.58) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL19514765 | 0.71 | TUBB1 (0.63) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| Combretastatin SCHEMBL5980835 | 0.69 | TUBB1 (0.85) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL25657154 | 0.68 | LDHA (0.53) | LDHAALDH1A1ALOX15ALOX12 | |
| SCHEMBL28655383 | 0.68 | KDM4E (0.41) | TUBB1TUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2289521-A2 | Compositions and methods for use in tergeting vascular destruction | ARIZONA BOARD OF REGENTS (US) | 2011-03-02 | — | — | EP | claimed |