Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6073621 | 0.77 | MEN1 (0.43) | ALDH1A1HTTMEN1KMT2ACYP3A4 | |
| SCHEMBL15099894 | 0.74 | ALDH1A1 (0.47) | ALDH1A1PPARGPPARDPPARAHTT | |
| SCHEMBL18560503 | 0.73 | ALDH1A1 (0.42) | ALDH1A1PPARGPPARDPPARAHTT | |
| SCHEMBL4158236 | 0.73 | MEN1 (0.47) | ALDH1A1HTTMEN1KMT2ACYP3A4 | |
| SCHEMBL8558796 | 0.73 | KMT2A (0.47) | ALDH1A1HTTMEN1KMT2ACYP3A4 | |
| SCHEMBL6074247 | 0.72 | ALDH1A1 (0.46) | ALDH1A1HTTMEN1KMT2ACYP3A4 | |
| SCHEMBL2031745 | 0.71 | MEN1 (0.46) | ALDH1A1HTTMEN1KMT2ACYP3A4 | |
| SCHEMBL15091095 | 0.70 | MEN1 (0.42) | ALDH1A1HTTMEN1KMT2ACYP3A4 | |
| SCHEMBL7075743 | 0.69 | ALDH1A1 (0.63) | ALDH1A1PPARGPPARDPPARAHTT | |
| SCHEMBL3958628 | 0.69 | GABRA1 (0.55) | ALDH1A1PPARGPPARDPPARAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10112928-B2 | Inhibitors of SYK | HOFFMANN-LA ROCHE INC. (US) | 2018-10-30 | — | — | US | disclosed |
| EP-2802567-B1 | PYRIDAZINE AMIDE COMPOUNDS AND THEIR USE AS SYK INHIBITORS | HOFFMANN LA ROCHE (CH) | 2017-03-01 | — | — | EP | disclosed |
| EP-2802567-B1 | PYRIDAZINE AMIDE COMPOUNDS AND THEIR USE AS SYK INHIBITORS | HOFFMANN LA ROCHE (CH) | 2017-03-01 | — | — | EP | disclosed |
| US-20150284367-A1 | INHIBITORS OF SYK | HOFFMANN-LA ROCHE INC. | 2015-10-08 | — | — | US | disclosed |
| US-20150284367-A1 | INHIBITORS OF SYK | HOFFMANN-LA ROCHE INC. | 2015-10-08 | — | — | US | disclosed |
| EP-2909174-A1 | INHIBITORS OF SYK | F. Hoffmann-La Roche AG (CH) | 2015-08-26 | — | — | EP | disclosed |
| US-8901124-B2 | Pyridazine amide compounds useful as SYK inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2014-12-02 | — | — | US | disclosed |
| US-8901124-B2 | Pyridazine amide compounds useful as SYK inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2014-12-02 | — | — | US | disclosed |
| EP-2802567-A1 | PYRIDAZINE AMIDE COMPOUNDS AND THEIR USE AS SYK INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-11-19 | — | — | EP | disclosed |
| WO-2014060371-A1 | INHIBITORS OF SYK | F. HOFFMANN-LA ROCHE AG (CH) | 2014-04-24 | — | — | WO | disclosed |
| WO-2014060371-A1 | INHIBITORS OF SYK | F. HOFFMANN-LA ROCHE AG (CH) | 2014-04-24 | — | — | WO | disclosed |
| WO-2013104573-A1 | PYRIDAZINE AMIDE COMPOUNDS AND THEIR USE AS SYK INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-07-18 | — | — | WO | disclosed |
| WO-2013104573-A1 | PYRIDAZINE AMIDE COMPOUNDS AND THEIR USE AS SYK INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-07-18 | — | — | WO | disclosed |
| US-20130178478-A1 | PYRIDAZINE AMIDE COMPOUNDS | HOFFMAN-LA ROCHE INC. (US) | 2013-07-11 | — | — | US | disclosed |
| US-20130178478-A1 | PYRIDAZINE AMIDE COMPOUNDS | HOFFMAN-LA ROCHE INC. (US) | 2013-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130178478-A1 | PYRIDAZINE AMIDE COMPOUNDS | SYK, BTK, IRAK2 | ALDH1A1 3705/4885PPARG 2372/4885PPARD 1468/4885 |
| US-20150284367-A1 | INHIBITORS OF SYK | SYK, BTK, LYN | ALDH1A1 4489/4885PPARG 4571/4885PPARD 3762/4885 |
| US-10112928-B2 | Inhibitors of SYK | SYK, BTK, LYN | ALDH1A1 4489/4885PPARG 4571/4885PPARD 3762/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.