Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | PPARA | Q07869 | 2/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15099894 | 0.77 | ALDH1A1 (0.47) | ALDH1A1PPARAPPARGPPARDKDM4E | |
| SCHEMBL15091075 | 0.73 | ALDH1A1 (0.41) | ALDH1A1PPARAPPARGPPARDKDM4E | |
| SCHEMBL13072949 | 0.69 | NQO2 (0.36) | ALDH1A1KDM4EL3MBTL1SMN1; SMN2LMNA | |
| SCHEMBL18560621 | 0.68 | KDM4E (0.33) | ALDH1A1KDM4EHPGDCYP3A4MEN1 | |
| SCHEMBL14215922 | 0.67 | GABRA1 (0.51) | ALDH1A1PPARAPPARGPPARDPTGS1 | |
| SCHEMBL23876228 | 0.64 | ALDH1A1 (0.65) | ALDH1A1PPARAPPARGPPARDKDM4E | |
| SCHEMBL14188932 | 0.64 | FDPS (0.38) | ALDH1A1PPARAPPARGPPARDKDM4E | |
| SCHEMBL16150885 | 0.61 | ALDH1A1 (0.53) | ALDH1A1PPARAPPARGPPARDKDM4E | |
| SCHEMBL8908376 | 0.60 | ALDH1A1 (0.51) | ALDH1A1PPARAPPARGPPARDKDM4E | |
| Methyleugenol SCHEMBL113794 | 0.60 | ALDH1A1 (1.00) | ALDH1A1PPARAPPARGPPARDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2802567-B1 | PYRIDAZINE AMIDE COMPOUNDS AND THEIR USE AS SYK INHIBITORS | HOFFMANN LA ROCHE (CH) | 2017-03-01 | — | — | EP | disclosed |