SCHEMBL15094707

SCHEMBL15094707

Cn1ncc2cc(C(c3ccc4c(cnn4C)c3)N3CCN(C(=O)OC(C(F)(F)F)C(F)(F)F)CC3)ccc21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ ABHD6 Q9BV23 13/20 1.00
▸ MGLL Q99685 11/20 1.00
▸ PLA2G7 Q13093 7/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15094172 0.84 PLA2G7 (0.73) ABHD6MGLLPLA2G7
SCHEMBL31023771 0.84 PLA2G7 (0.73) ABHD6MGLLPLA2G7
SCHEMBL21802546 0.81 PLA2G7 (0.68) ABHD6MGLLPLA2G7
SCHEMBL15266851 0.80 MGLL (0.66) ABHD6MGLLPLA2G7
SCHEMBL15100763 0.75 MGLL (0.79) ABHD6MGLLPLA2G7
SCHEMBL15095078 0.74 MGLL (0.59) ABHD6MGLLPLA2G7
SCHEMBL15266976 0.74 PLA2G7 (0.58) ABHD6MGLLPLA2G7
SCHEMBL15100761 0.74 ABHD6 (0.77) ABHD6MGLLPLA2G7
SCHEMBL15100884 0.74 MGLL (1.00) ABHD6MGLLPLA2G7
SCHEMBL21802510 0.74 PLA2G7 (0.59) ABHD6MGLLPLA2G7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210188793-A1 CARBAMATE COMPOUNDS AND METHODS OF MAKING AND USING SAME LUNDBECK LA JOLLA RESEARCH CENTER, INC. 2021-06-24 — — US claimed
EP-2800565-B1 CARBAMATE COMPOUNDS AND METHODS OF MAKING AND USING SAME LUNDBECK LA JOLLA RESEARCH CENTER INC (US) 2020-03-25 — — EP claimed
US-20180208568-A1 CARBAMATE COMPOUNDS AND METHODS OF MAKING AND USING SAME H. LUNDBECK A/S (DK) 2018-07-26 — — US claimed
US-9487495-B2 Carbamate compounds and of making and using same THE SCRIPTS RESEARCH INSTITUTE (US) 2016-11-08 — — US claimed
EP-2800565-A1 CARBAMATE COMPOUNDS AND OF MAKING AND USING SAME Abide Therapeutics, Inc. (US) 2014-11-12 — — EP claimed
WO-2013103973-A1 CARBAMATE COMPOUNDS AND OF MAKING AND USING SAME ABIDE THERAPEUTICS (US) 2013-07-11 — — WO claimed
US-12018004-B2 Carbamate compounds and methods of making and using same H. LUNDBECK A/S (DK) 2024-06-25 — — US disclosed
US-20230312499-A1 CARBAMATE COMPOUNDS AND METHODS OF MAKING AND USING SAME H. LUNDBECK A/S (DK) 2023-10-05 — — US disclosed
US-20230312499-A1 CARBAMATE COMPOUNDS AND METHODS OF MAKING AND USING SAME H. LUNDBECK A/S (DK) 2023-10-05 — — US disclosed
US-20230312499-A1 CARBAMATE COMPOUNDS AND METHODS OF MAKING AND USING SAME H. LUNDBECK A/S (DK) 2023-10-05 — — US disclosed
US-11530189-B2 Carbamate compounds and methods of making and using same H. LUNDBECKA/S (DK) 2022-12-20 — — US disclosed
US-11530189-B2 Carbamate compounds and methods of making and using same H. LUNDBECKA/S (DK) 2022-12-20 — — US disclosed
CN-107982266-B Carbamate compounds and methods of making and using the same H.隆德贝克有限公司 2021-07-30 — — CN disclosed
US-9133148-B2 Carbamate compounds and of making and using same THE SCRIPPS RESEARCH INSTITUTE (US) 2015-09-15 — — US disclosed
US-9133148-B2 Carbamate compounds and of making and using same THE SCRIPPS RESEARCH INSTITUTE (US) 2015-09-15 — — US disclosed
US-9133148-B2 Carbamate compounds and of making and using same THE SCRIPPS RESEARCH INSTITUTE (US) 2015-09-15 — — US disclosed
US-20150148330-A1 CARBAMATE COMPOUNDS AND OF MAKING AND USING SAME H. LUNDBECK A/S (DK) 2015-05-28 — — US disclosed
US-20150148330-A1 CARBAMATE COMPOUNDS AND OF MAKING AND USING SAME H. LUNDBECK A/S (DK) 2015-05-28 — — US disclosed
US-20150148330-A1 CARBAMATE COMPOUNDS AND OF MAKING AND USING SAME H. LUNDBECK A/S (DK) 2015-05-28 — — US disclosed
WO-2013103973-A1 CARBAMATE COMPOUNDS AND OF MAKING AND USING SAME ABIDE THERAPEUTICS (US) 2013-07-11 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11530189-B2 Carbamate compounds and methods of making and using same ABHD6, ABHD16A, RABL6 ABHD6 1/4885MGLL 54/4885PLA2G7 195/4885
US-20210188793-A1 CARBAMATE COMPOUNDS AND METHODS OF MAKING AND USING SAME ABHD6, ABHD16A, RABL6 ABHD6 1/4885MGLL 54/4885PLA2G7 195/4885
US-20180208568-A1 CARBAMATE COMPOUNDS AND METHODS OF MAKING AND USING SAME ABHD6, ABHD16A, NCEH1 ABHD6 1/4885MGLL 14/4885PLA2G7 277/4885
US-20230312499-A1 CARBAMATE COMPOUNDS AND METHODS OF MAKING AND USING SAME ABHD6, ABHD16A, RABL6 ABHD6 1/4885MGLL 54/4885PLA2G7 195/4885
US-20150148330-A1 CARBAMATE COMPOUNDS AND OF MAKING AND USING SAME ABHD6, ABHD16A, PRMT6 ABHD6 1/4885MGLL 16/4885PLA2G7 320/4885
US-12018004-B2 Carbamate compounds and methods of making and using same ABHD6, ABHD16A, RABL6 ABHD6 1/4885MGLL 54/4885PLA2G7 195/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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