Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.44 |
| ▸ | ATM | Q13315 | 2/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 4/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22044586 | 0.87 | AKT1 (0.48) | POLBNPSR1MEN1KMT2ATDP1 | |
| SCHEMBL31467206 | 0.87 | TDP1 (0.51) | POLBNPSR1MEN1KMT2ATDP1 | |
| SCHEMBL8648133 | 0.85 | SIRT2 (0.47) | SIRT2SIRT1SIRT3 | |
| SCHEMBL22807658 | 0.84 | GLP1R (0.43) | POLBNPSR1MEN1KMT2ATDP1 | |
| SCHEMBL21664570 | 0.84 | TDP1 (0.49) | POLBNPSR1MEN1KMT2ATDP1 | |
| SCHEMBL18942764 | 0.84 | AKT1 (0.52) | NPSR1TDP1ATMAKT1HDAC1 | |
| SCHEMBL15096521 | 0.84 | PTGS1 (0.47) | SIRT2SIRT1SIRT3 | |
| SCHEMBL12148796 | 0.83 | AKT1 (0.51) | POLBNPSR1MEN1KMT2ATDP1 | |
| SCHEMBL31721990 | 0.83 | AKT1 (0.51) | AKT1HDAC1HDAC8HDAC3HDAC6 | |
| SCHEMBL17738032 | 0.82 | TDP1 (0.56) | NPSR1MEN1KMT2ATDP1AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180104353-A1 | LIGAND-TARGETED MOLECULES AND METHODS THEREOF | INVICTUS ONCOLOGY PVT. LTD. (IN) | 2018-04-19 | — | — | US | disclosed |
| US-9884123-B2 | Ligand-targeted molecules and methods thereof | INVICTUS ONCOLOGY PVT. LTD. (IN) | 2018-02-06 | — | — | US | disclosed |
| US-20150045428-A1 | LIGAND-TARGETED MOLECULES AND METHODS THEREOF | INVICTUS ONCOLOGY PVT. LTD. (IN) | 2015-02-12 | — | — | US | disclosed |
| WO-2013103707-A1 | LIGAND-TARGETED MOLECULES AND METHODS THEREOF | INVICTUS ONCOLOGY PVT. LTD. (IN) | 2013-07-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180104353-A1 | LIGAND-TARGETED MOLECULES AND METHODS THEREOF | HLCS, PAICS, CLTC | POLB 3615/4885NPSR1 1252/4885MEN1 1456/4885 |
| US-20150045428-A1 | LIGAND-TARGETED MOLECULES AND METHODS THEREOF | HLCS, PAICS, CLTC | POLB 3695/4885NPSR1 1144/4885MEN1 1473/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.