Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 4/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | PREP | P48147 | 1/20 | 0.36 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.36 |
| ▸ | CTSD | P07339 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13779825 | 1.00 | MAPT (0.48) | MAPTMEN1ALDH1A1KMT2AUSP2 | |
| SCHEMBL8004062 | 1.00 | MAPT (0.48) | MAPTMEN1ALDH1A1KMT2AUSP2 | |
| SCHEMBL60605 | 0.92 | USP2 (0.51) | MAPTMEN1ALDH1A1KMT2AUSP2 | |
| SCHEMBL555079 | 0.92 | USP2 (0.51) | MAPTMEN1ALDH1A1KMT2AUSP2 | |
| SCHEMBL554849 | 0.92 | USP2 (0.51) | MAPTMEN1ALDH1A1KMT2AUSP2 | |
| Hydrochloric Acid SCHEMBL31601582 | 0.90 | USP2 (0.50) | MAPTMEN1ALDH1A1KMT2AUSP2 | |
| Acetic Acid SCHEMBL31055697 | 0.88 | USP2 (0.48) | MAPTMEN1ALDH1A1KMT2AUSP2 | |
| SCHEMBL305277 | 0.87 | PDK1 (0.52) | MAPTMEN1ALDH1A1KMT2AUSP2 | |
| SCHEMBL305278 | 0.87 | PDK1 (0.52) | MAPTMEN1ALDH1A1KMT2AUSP2 | |
| SCHEMBL306580 | 0.87 | PDK1 (0.52) | MAPTMEN1ALDH1A1KMT2AUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130274475-A1 | BETA-LACTAMASE INHIBITORS | MERCK SHARP & DOHME (US) | 2013-10-17 | — | — | US | disclosed |
| US-8487093-B2 | β-lactamase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2013-07-16 | — | — | US | disclosed |
| US-20110294777-A1 | BETA-LACTAMASE INHIBITORS | MERCK SHARP & DOHME CORP. | 2011-12-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110294777-A1 | BETA-LACTAMASE INHIBITORS | MGAM, RPIA, LBR | MAPT 3486/4885MEN1 3789/4885ALDH1A1 307/4885 |
| US-20130274475-A1 | BETA-LACTAMASE INHIBITORS | MGAM, RPIA, XDH | MAPT 3438/4885MEN1 3883/4885ALDH1A1 422/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.