Sugi Predict

Sugi Predict / Compounds / SCHEMBL305278

SCHEMBL305278

SCHEMBL305278

CC(C)(C)OC(=O)N1CCCOC(CO)C1

nearest known ligand 0.52

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ PDK1 Q15118 6/20 0.52
▸ MAPT P10636 2/20 0.49
▸ MEN1 O00255 1/20 0.49
▸ ALDH1A1 P00352 1/20 0.49
▸ KMT2A Q03164 1/20 0.49
▸ NR1H2 P55055 1/20 0.48
▸ HPGD P15428 1/20 0.47
▸ USP2 O75604 1/20 0.46
▸ SMN1; SMN2 Q16637 1/20 0.46
▸ RECQL P46063 1/20 0.45
▸ PREP P48147 1/20 0.40
▸ EPHX1 P07099 1/20 0.39
▸ KDM4E B2RXH2 1/20 0.39
▸ THRB P10828 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL305277 1.00 PDK1 (0.52) PDK1MAPTMEN1ALDH1A1KMT2A
SCHEMBL306580 1.00 PDK1 (0.52) PDK1MAPTMEN1ALDH1A1KMT2A
SCHEMBL30987096 0.96 HPGD (0.49) PDK1MAPTMEN1ALDH1A1KMT2A
SCHEMBL304803 0.91 USP2 (0.53) PDK1MAPTMEN1ALDH1A1KMT2A
SCHEMBL553919 0.91 USP2 (0.53) PDK1MAPTMEN1ALDH1A1KMT2A
SCHEMBL8904969 0.91 USP2 (0.53) PDK1MAPTMEN1ALDH1A1KMT2A
SCHEMBL304804 0.91 USP2 (0.53) PDK1MAPTMEN1ALDH1A1KMT2A
SCHEMBL13779825 0.87 MAPT (0.48) PDK1MAPTMEN1ALDH1A1KMT2A
SCHEMBL22034145 0.87 MAPT (0.48) PDK1MAPTMEN1ALDH1A1KMT2A
SCHEMBL8004062 0.87 MAPT (0.48) PDK1MAPTMEN1ALDH1A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12319679-B2 Morpholinyl, piperazinyl, oxazepanyl and diazepanyl O-glycoprotein-2-acetamido-2-deoxy-3-d-glucopyranosidase inhibitors BIOGEN MA INC. (US) 2025-06-03 — — US disclosed
US-20250019377-A1 1, 4-OXAZEPANE DERIVATIVES AND USES THEREOF JACOBIO PHARMACEUTICALS CO., LTD. (CN) 2025-01-16 — — US disclosed
CN-118475575-A Peptidyl nitrile compound and application thereof 上海壹典医药科技开发有限公司 2024-08-09 — — CN disclosed
EP-4387967-A1 1, 4-OXAZEPANE DERIVATIVES AND USES THEREOF Jacobio Pharmaceuticals Co., Ltd. (CN) 2024-06-26 — — EP disclosed
CN-118139855-A 1, 4-Oxaazepane derivatives and their use 北京加科思新药研发有限公司 2024-06-04 — — CN disclosed
EP-4327814-A2 MORPHOLINYL, PIPERAZINYL, OXAZEPANYL AND DIAZEPANYL O-GLYCOPROTEIN-2-ACETAMIDO-2-DEOXY-3-D-GLUCOPYRANOSIDASE INHIBITORS Biogen MA Inc. (US) 2024-02-28 — — EP disclosed
US-20230312557-A1 P2X3 MODULATORS GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.3) LIMITED (GB) 2023-10-05 — — US disclosed
EP-3891146-B1 MORPHOLINYL, PIPERAZINYL, OXAZEPANYL AND DIAZEPANYL DERIVATIVES USEFUL AS O-GLYCOPROTEIN-2-ACETAMIDO-2-DEOXY-3-D-GLUCOPYRANOSIDASE INHIBITORS BIOGEN MA INC (US) 2023-09-27 — — EP disclosed
CN-116462672-A Novel peptide-based nitrile compound and application thereof 上海壹典医药科技开发有限公司 2023-07-21 — — CN disclosed
WO-2023134656-A1 PEPTIDYL NITRILE COMPOUND AND USE THEREOF 上海壹典医药科技开发有限公司 2023-07-20 — — WO disclosed
EP-2330105-A1 Heteroaryl urea derivatives useful for inhibiting CHK1 ICOS Corporation (US) 2011-06-08 — — EP disclosed
EP-1869020-B1 HETEROARYL UREA DERIVATIVES USEFUL FOR INHIBITING CHK1 ICOS CORP (US) 2010-12-01 — — EP disclosed
WO-2010077915-A1 NOVEL COMPOUNDS USEFUL AS CC CHEMOKINE RECEPTOR LIGANDS FOREST LABORATORIES HOLDINGS LIMITED (BM) 2010-07-08 — — WO disclosed
US-20100168080-A1 NOVEL COMPOUNDS USEFUL AS CC CHEMOKINE RECEPTOR LIGANDS KHAMRAI UTTAM 2010-07-01 — — US disclosed
US-20100168080-A1 NOVEL COMPOUNDS USEFUL AS CC CHEMOKINE RECEPTOR LIGANDS KHAMRAI UTTAM 2010-07-01 — — US disclosed
US-20100168080-A1 NOVEL COMPOUNDS USEFUL AS CC CHEMOKINE RECEPTOR LIGANDS KHAMRAI UTTAM 2010-07-01 — — US disclosed
WO-2009091856-A2 BETA-LACTAMASE INHIBITORS MERCK & CO., INC. (US) 2009-07-23 — — WO disclosed
US-20090143357-A1 HETEROARYL UREA DERIVATIVES USEFUL FOR INHIBITING CHK1 ICOS CORPORATION (US) 2009-06-04 — — US disclosed
EP-1869020-A1 HETEROARYL UREA DERIVATIVES USEFUL FOR INHIBITING CHKl ICOS Corporation (US) 2007-12-26 — — EP disclosed
WO-2006105262-A1 HETEROARYL UREA DERIVATIVES USEFUL FOR INHIBITING CHKl ICOS CORPORATION (US) 2006-10-05 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230312557-A1 P2X3 MODULATORS P2RX3, P2RX2, P2RX6 PDK1 1435/4885MAPT 2905/4885MEN1 4645/4885
US-20250019377-A1 1, 4-OXAZEPANE DERIVATIVES AND USES THEREOF CYP11B2, CYP21A2, CYP11B1 PDK1 310/4885MAPT 2563/4885MEN1 1708/4885
US-12319679-B2 Morpholinyl, piperazinyl, oxazepanyl and diazepanyl O-glycoprotein-2-acetamido-2-deoxy-3-d-glucopyranosidase inhibitors MAN2A1, MAN2B2, MGAT3 PDK1 1670/4885MAPT 3138/4885MEN1 2973/4885
US-20090143357-A1 HETEROARYL UREA DERIVATIVES USEFUL FOR INHIBITING CHK1 CHEK1, CHEK2, PCNA PDK1 993/4885MAPT 2615/4885MEN1 2085/4885
US-20100168080-A1 NOVEL COMPOUNDS USEFUL AS CC CHEMOKINE RECEPTOR LIGANDS CCR1, CCR5, CCR3 PDK1 3410/4885MAPT 4424/4885MEN1 4235/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.