Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 18/20 | 0.72 |
| ▸ | PPARG | P37231 | 2/20 | 0.57 |
| ▸ | PPARD | Q03181 | 2/20 | 0.57 |
| ▸ | PPARA | Q07869 | 2/20 | 0.57 |
| ▸ | HTR1A | P08908 | 2/20 | 0.53 |
| ▸ | DRD2 | P14416 | 2/20 | 0.53 |
| ▸ | HTR1D | P28221 | 2/20 | 0.53 |
| ▸ | HTR1B | P28222 | 2/20 | 0.53 |
| ▸ | HTR1F | P30939 | 2/20 | 0.53 |
| ▸ | HTR7 | P34969 | 2/20 | 0.53 |
| ▸ | DRD3 | P35462 | 2/20 | 0.53 |
| ▸ | HTR1E | P28566 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1518941 | 1.00 | HTR6 (0.72) | HTR6PPARGPPARDPPARAHTR1A | |
| SCHEMBL1519041 | 1.00 | HTR6 (0.72) | HTR6PPARGPPARDPPARAHTR1A | |
| SCHEMBL1518928 | 1.00 | HTR6 (0.72) | HTR6PPARGPPARDPPARAHTR1A | |
| SCHEMBL5355855 | 0.89 | PPARG (0.72) | HTR6PPARGPPARDPPARAHTR1A | |
| SCHEMBL5350317 | 0.89 | PPARG (0.72) | HTR6PPARGPPARDPPARAHTR1A | |
| SCHEMBL5355639 | 0.89 | PPARG (0.72) | HTR6PPARGPPARDPPARAHTR1A | |
| SCHEMBL5359036 | 0.89 | HTR6 (0.61) | HTR6PPARGPPARDPPARAHTR1A | |
| SCHEMBL5371298 | 0.89 | PPARG (0.72) | HTR6PPARGPPARDPPARAHTR1A | |
| SCHEMBL945681 | 0.87 | HTR6 (0.76) | HTR6PPARGPPARDPPARA | |
| SCHEMBL5361339 | 0.84 | HTR6 (0.59) | HTR6PPARGPPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7902249-B2 | Central nervous system disorders; oxidation resistance; antitumor agents; Alzheimer's disease; 3-(2-hydroxyethyl)indole | MEIJI DAIRIES CORPORATION (JP) | 2011-03-08 | — | — | US | disclosed |
| EP-1474390-B1 | INDOLE DERIVATIVES SUBSTITUTED WITH LONG-CHAIN ALCOHOLS AND MEDICAMENTS CONTAINING THEM | MEIJI DAIRIES CORP (JP) | 2009-07-22 | — | — | EP | disclosed |
| US-20080234357-A1 | Indole derivatives substituted with long-chain alcohols and medicaments containing them | MEIJI DAIRIES CORPORATION (JP) | 2008-09-25 | — | — | US | disclosed |
| US-7407983-B2 | Indole derivatives substituted with long-chain alcohols and medicaments containing them | MEIJI DAIRIES CORPORATION (JP) | 2008-08-05 | — | — | US | disclosed |
| US-20050131053-A1 | Indole derivatives substituted with long-chain alcolhols and medicaments containing them | MEIJI DAIRIES CORPORATION (JP) | 2005-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234357-A1 | Indole derivatives substituted with long-chain alcohols and medicaments containing them | NGF, BDNF, ADH1A | HTR6 200/4885PPARG 900/4885PPARD 2244/4885 |
| US-20050131053-A1 | Indole derivatives substituted with long-chain alcolhols and medicaments containing them | IDO1, CBLC, PIK3C3 | HTR6 461/4885PPARG 1608/4885PPARD 1711/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.